Juvista (Avotermin) in Scars Following Varicose Vein Removal
Study Details
Study Description
Brief Summary
This trial is being undertaken to investigate the efficacy and safety of Juvista in the improvement of scar appearance when administered to approximated wound margins following varicose vein surgery. The results from this trial will be used to select doses for investigation in future clinical trials with the compound.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
| Phase 2 |
Detailed Description
Patients undergoing bilateral removal of the saphenous vein (by ligation and stripping) will be invited to participate in the study. Consenting patients will undergo a detailed screening examination, after which suitability to progress to randomisation to the study will be confirmed.
Suitable screened patients will attend for scheduled surgery of vein removal as normal - this is termed "Day 0" At the time of wound closure, IMP will be administered via intra-dermal injection to each of the incisional groin wounds, and exit wounds.
Each patient will serve as their own control with one leg being administered active IMP (at either a 5, 50, 200 or 500ng/100 ul)of dose solution, whilst the other leg is administered placebo solution. The study is double-blinded, so neither the Investigator nor patient will know which leg wounds receive which treatment.
Further to Day 0, the patients are requested to attend for a further 5 follow up visits (Week 6, Month 3, Month 5, Month 7 & Month 12), where photographs of the scars will be taken, together with spectrophotometry readings to measure colour of the scar. At each visit, the Investigator and patient will rate their opinion of the scar, by global assessment scale & VAS, together with patient completed questionnaires.
Study Design
Outcome Measures
Primary Outcome Measures
- Investigator scar assessment [7 & 12 months]
- Patient scar assessment [up to 12 months]
- Independent scar assessment [7 & 12 months]
Secondary Outcome Measures
- Local tolerance [ongoing to 12 months]
- Adverse events [ongoing to12 months]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Male and female patients between 18 and 85 years of age.
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Patients undergoing surgical removal of bilateral varicose veins by ligation and stripping, which will result in clinically similar (i.e. size and location) wounds at the groin and knee.
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Patients who have provided written informed consent.
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Patients with a body mass index between 15 and 35 kg/m2 inclusive.
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Patients with, in the opinion of the Investigator, clinically acceptable results for the laboratory tests specified in the trial protocol (see Protocol Section 6.4.1).
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Female patients of child bearing potential using method(s) of contraception acceptable to the Investigator and who agree to do so from at least the screening visit until one month after administration of the Investigational Medicinal Product.
Exclusion Criteria:
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Patients who have had previous surgical treatment for varicose veins.
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Patients with a history of a bleeding disorder.
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Patients with a chronic or currently active skin disorder which may adversely affect the healing of the acute wounds or involves the areas to be examined in this trial.
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Patients who on direct questioning and/or physical examination, have evidence of any past or present clinically significant medical condition that would impair wound healing.
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Patients who are taking or have taken investigational drugs in the 3 months prior to the screening visit.
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Patients with existing scars within 3cm of the potential trial wounds.
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Patients with diseases or conditions that could, in the opinion of the Investigator, interfere with the assessment of safety, tolerability or efficacy of the Investigational Product.
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Patients with a history of clinically significant hypersensitivity to any of the drugs or surgical dressings to be used in this trial.
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Patients who are taking regular, continuous, oral corticosteroid therapy.
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Patients undergoing investigations or changes in management for an existing medical condition.
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Patients who are pregnant or lactating.
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Patients who, in the opinion of the Investigator, are not likely to complete the trial.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Ziekenhuis Oost Limburg | Genk | Belgium | ||
| 2 | Universitair Ziekenhuis Gent | Gent | Belgium | ||
| 3 | P Stradinas Clinical University Hospital | Riga | Latvia | ||
| 4 | Kaunas 2nd Clinical Hospital | Kaunas | Lithuania | ||
| 5 | Klaipeda Seaman Hospital | Klaipeda | Lithuania | ||
| 6 | Vilnius City University Hospital | Vilnius | Lithuania | ||
| 7 | Belfast City Hospital | Belfast | United Kingdom | BT9 7AB | |
| 8 | Heartlands Hospital | Birmingham | United Kingdom | B9 5SS | |
| 9 | Royal Bournemouth Hospital | Bournemouth | United Kingdom | BH7 7DW | |
| 10 | Bristol Royal Infirmary | Bristol | United Kingdom | BS2 8HW | |
| 11 | Derby City General Hospital | Derby | United Kingdom | DE22 3NE | |
| 12 | Russells Hall Hospital | Dudley | United Kingdom | DY1 2HQ | |
| 13 | Royal Infirmary of Edinburgh | Edinburgh | United Kingdom | EH16 4SA | |
| 14 | Gloucester Royal Hospital | Gloucester | United Kingdom | GL1 3NN | |
| 15 | Hull Royal Infirmary | Hull | United Kingdom | HU3 2JZ | |
| 16 | Leeds General Infirmary | Leeds | United Kingdom | LS1 3EX | |
| 17 | St Georges Hospital | London | United Kingdom | SW17 0OT | |
| 18 | St Mary's Hospital | London | United Kingdom | W2 1NY | |
| 19 | Wythenshawe Hospital | Manchester | United Kingdom | M23 9LT | |
| 20 | Freeman Hospital | Newcastle | United Kingdom | NE7 7DN | |
| 21 | Norfolk & Norwich University Hospital | Norwich | United Kingdom | NR4 7UY |
Sponsors and Collaborators
- Renovo
- ICON Clinical Research
Investigators
- Principal Investigator: Peter McCollum, MB MCh FRCS, Hull Royal Infirmary
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- RN1001-0042