Effects of COP Exercise and HIIT on Vascular Health in Young Overweight Females

Sponsor

Beijing Sport University (Other)

Overall Status

Completed

CT.gov ID

NCT05817487

Collaborator

(none)

Enrollment

Location

Arms

8.2

Actual Duration (Months)

2.4

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The goal of this study is to determine the effects of high-intensity interval training and crossover point exercise training on vascular health in young overweight women.

Condition or Disease	Intervention/Treatment	Phase
Vascular Diseases	Behavioral: high-intensity interval training (HIIT) Behavioral: crossover point(COP) exercise training	N/A

Detailed Description

In recent years, improving cardiovascular health through exercise has become a popular research question, however, it is not clear which intensity and modes of exercise bring more benefits. Crossover point(COP) intensity has great medical potential as a personalized exercise intensity that is based on substrate utilization mode, especially in overweight and obese people.On the other hand, several studies have demonstrated that HIIT is an effective method in improving vascular endothelial dysfunction. During our study, we evaluated the vascular health changes in young overweight women who received either COP exercise or HIIT exercise for 10 weeks.

Study Design

Study Type:

Interventional

Actual Enrollment :

20 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Primary Purpose:

Prevention

Official Title:

Effects of Crossover Point Exercise and High-intensity Interval Training on Vascular Health in Young Overweight Females

Actual Study Start Date :

Feb 18, 2019

Actual Primary Completion Date :

Jul 5, 2019

Actual Study Completion Date :

Oct 25, 2019

Arms and Interventions

Arm	Intervention/Treatment
Experimental: HIIT group	Behavioral: high-intensity interval training (HIIT) Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The training sessions in the HIIT group involved five high-intensity intervals of 4 minutes each (running or walking on a treadmill) at 85% VO2max interspersed with 3 minutes of low-intensity walking.
Experimental: COP group	Behavioral: crossover point(COP) exercise training Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The COP exercise training sessions involved 45 minutes of continuous exercise at the COP on a treadmill.

Arm

Intervention/Treatment

Experimental: HIIT group

Behavioral: high-intensity interval training (HIIT)

Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The training sessions in the HIIT group involved five high-intensity intervals of 4 minutes each (running or walking on a treadmill) at 85% VO2max interspersed with 3 minutes of low-intensity walking.

Experimental: COP group

Behavioral: crossover point(COP) exercise training

Participants in both the COP and HIIT groups underwent 30 sessions of exercise performed over 10 weeks. The COP exercise training sessions involved 45 minutes of continuous exercise at the COP on a treadmill.

Outcome Measures

Primary Outcome Measures

brachial-ankle pulse wave velocity (baPWV) [10 weeks]
The change of baPWV before and after intervention
blood pressure [10 weeks]
The change of blood pressure before and after intervention

Secondary Outcome Measures

Interleukin 6 (IL-6) [10 weeks]
The change of IL-6 level before and after intervention
Homocysteine (HCY) [10 weeks]
The change of HCY level before and after intervention

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

Female

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Female, 18-30 years old
Body mass index (BMI) < 28 kg/m2 and ≥ 24 kg/m2
No exercise habit, and no recent new exercise plan
No contraindications to exercise

Exclusion Criteria:

Participates had an orthopedic or other condition that limited participation in daily exercise
Participates had a history of myocardial infarction, stroke, diabetes mellitus, chronic respiratory disease or cancer
Participates had smoking or alcohol behavior

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Beijing Sport University	Beijing		China

Sponsors and Collaborators

Beijing Sport University

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Beijing Sport University

ClinicalTrials.gov Identifier:

NCT05817487

Other Study ID Numbers:

EOCPEAHITOVHIYOF

First Posted:

Apr 18, 2023

Last Update Posted:

Apr 18, 2023

Last Verified:

Apr 1, 2023

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Additional relevant MeSH terms:

Vascular Diseases

Overweight

Study Results

No Results Posted as of Apr 18, 2023