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Vascular and Periodontal Disease - Microbial, Genetic and Histological Causalities

Sponsor
University of Oslo (Other)
Overall Status
Unknown status
CT.gov ID
NCT01358630
Collaborator
Oslo University Hospital (Other)
100
Enrollment
1
Location
84
Duration (Months)
1.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of this study is to analyze genetic polymorphisms in genes encoding pro-inflammatory cytokines, and study the genetic predisposition to chronic periodontitis (CP) in combination with atherosclerotic cardiovascular (ACD) and aneurysmal diseases. The investigators will also try to identify oral bacteria in atherosclerotic plaques and aneurysmal walls and thrombus. Histological analyses of atherosclerotic plaques and aneurysmal wall will be performed.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    100 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Official Title:
    Periodontal-, Cardiovascular- and Aneurysmal Diseases.
    Study Start Date :
    Oct 1, 2008
    Actual Primary Completion Date :
    Mar 1, 2011
    Anticipated Study Completion Date :
    Oct 1, 2015

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      N/A and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • Patients undergoing vascular surgery at Oslo University Hospital, Aker, previously randomly collected patients with periodontitis,
      Exclusion Criteria:

      • patients whom undergone antibiotic treatment the past month.

      • patients whom undergone periodontal treatment the past 6 months.

      • patients with no teeth

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Dental and Medical Faculty, University of Oslo Oslo Norway 0316

      Sponsors and Collaborators

      • University of Oslo
      • Oslo University Hospital

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT01358630
      Other Study ID Numbers:
      • 08/322b
      First Posted:
      May 24, 2011
      Last Update Posted:
      May 24, 2011
      Last Verified:
      Nov 1, 2010
      Keywords provided by , ,
      Periodontitis
      Vascular disease
      Proinflammatory cytokines
      Additional relevant MeSH terms:
      Periodontitis
      Vascular Diseases

      Study Results

      No Results Posted as of May 24, 2011