Clincosm LogoSign in Get a demo

Vascular Sensitivity to Adrenergic Agonists in Patients With CHF and in Healthy Subjects

Sponsor
Hadassah Medical Organization (Other)
Overall Status
Unknown status
CT.gov ID
NCT00782782
Collaborator
(none)
80
Enrollment
1
Location
40
Duration (Months)
2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Congestive Heart failure (CHF) is asociated with changes in cardiac function and vascular responses. The aim of this study is to characterize these differences. Our hypothesis is, that there are differences in vascular responses between healthy subjects and patients with CHF.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    80 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Effect of Medications on Vascular Response in Patients With CHF and in Healthy Subjects
    Study Start Date :
    Aug 1, 2008
    Anticipated Primary Completion Date :
    Dec 1, 2009
    Anticipated Study Completion Date :
    Dec 1, 2011

    Outcome Measures

    Primary Outcome Measures

    1. vascular sensitivity (ED50) and response (Emax) to dexmedetomidine, phenylephrine, isoproterenol and terbutaline [3 weeks]

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 70 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:

    • Patients with congestive heart failure NYHA I-II

    • Stable clinical condition

    Exclusion Criteria:

    • Resting systolic blood pressure < 100

    • Resting heart rate < 50

    • Hypersensitivity to dexmedetomidine, phenylephrine, isoproterenol, terbutaline

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Hadassah University Hospital Jerusalem Israel 92110

    Sponsors and Collaborators

    • Hadassah Medical Organization

    Investigators

    • Principal Investigator: Mordechai Muszkat, Hadassah University Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT00782782
    Other Study ID Numbers:
    • 366-28.12.07
    First Posted:
    Oct 31, 2008
    Last Update Posted:
    Oct 31, 2008
    Last Verified:
    Oct 1, 2008
    Additional relevant MeSH terms:
    Heart Failure

    Study Results

    No Results Posted as of Oct 31, 2008