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icc: VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway

Sponsor
First Affiliated Hospital, Sun Yat-Sen University (Other)
Overall Status
Unknown status
CT.gov ID
NCT01917370
Collaborator
Guangdong Province, Department of Science and Technology (Other)
20
Enrollment
1
Location
26
Duration (Months)
0.8
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigators study the VEGF signaling in ICC cell lines／human tissues and its mechanism in HCC growth, proliferation and apoptosis.

Condition or Disease Intervention/Treatment Phase
  • Procedure: surgical treatment

Detailed Description

Several studies have documented the elevated expression of VEGF and its receptors in ICC cell lines and tumor tissues. Another study observed that the elevation of VEGF promotes the growth. Clinical analyses have discovered the high expression of VEGF is correlated with tumor progression, vascular invasion, distal metastasis and poor prognosis. However, few studies have been conducted to investigate the VEGF signaling in ICC cells and its possible mechanism in regulating ICC growth.Therefore,we try to clarify the mechanism of VEGF signal in ICC growth,proliferation and apoptosis.

Study Design

Study Type:
Observational
Anticipated Enrollment :
20 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF
Study Start Date :
Oct 1, 2012
Anticipated Primary Completion Date :
Dec 1, 2013
Anticipated Study Completion Date :
Dec 1, 2014

Arms and Interventions

Arm Intervention/Treatment
ICC patients

patients with intrahepatic cholangiocarcinoma treated by surgical treatment

Procedure: surgical treatment
all the patients in the study must have been treated by the surgery at the first time and have been confirmed as 'complete section' by the post-surgery radiological image.
Other Names:
  • hepatectomy

    		•

    Outcome Measures

    Primary Outcome Measures

    1. the variation of the quantity of VEGF signal pathway genes in normal liver tissue,peri tumor,tumor and metastasis. [the day when conducting surgery (day 1)]

      the sections would be collected as previously described.Western blot,immunohistochemistry,PCR would be conducted to find out the variation between the normal liver tissue and tumor,tumor and meta(if have).

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    16 Years to 90 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    1. hepatocellular patients diagnosed through biopsy;or either dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma and CA199>100U/L；or two or more dynamic imagine with a diagnosis of intrahepatic cholangiocarcinoma

    2. Child-Pugh A or B

    3. well preserved renal and hematopoietic Function

    4. receive complete surgical therapy

    5. achieve complete section accessed by contrast-enhanced CT

    Exclusion Criteria:

    1. incomplete section

    2. Child-Pugh C

    3. combination with other hepatobiliary disease

    4. suffer from other tumors concurrently or in last five years

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 First Affiliated Hospital, Sun Yat-Sen University Guangzhou Guangdong China 510000

    Sponsors and Collaborators

    • First Affiliated Hospital, Sun Yat-Sen University
    • Guangdong Province, Department of Science and Technology

    Investigators

    • Principal Investigator: Ming Kuang, MD, First Affiliated Hospital, Sun Yat-Sen University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Ming Kuang,MD,PhD, MD,PhD, First Affiliated Hospital, Sun Yat-Sen University
    ClinicalTrials.gov Identifier:
    NCT01917370
    Other Study ID Numbers:
    • k0113011-2013ICC
    First Posted:
    Aug 6, 2013
    Last Update Posted:
    Aug 6, 2013
    Last Verified:
    Aug 1, 2013
    Keywords provided by Ming Kuang,MD,PhD, MD,PhD, First Affiliated Hospital, Sun Yat-Sen University
    intrahepatic cholangiocarcinoma
    icc
    vegf signal pathway
    Additional relevant MeSH terms:
    Cholangiocarcinoma

    Study Results

    No Results Posted as of Aug 6, 2013