ETCO2: End-tidal Carbon Dioxide Monitoring in Low Tidal Volume Ventilation
Study Details
Study Description
Brief Summary
In cases where there is no ventilation-perfusion problem, the end-tidal carbon dioxide (ETCO2) value is closely associated with partial arterial carbon dioxide pressure (PaCO2); therefore, the PaCO2 value can be estimated using ETCO2 measurements in patients without significant cardiopulmonary disorders. The aim of the investigator's study is to evaluate the reliability of pulmonary ventilation monitoring with ETCO2 value and to investigate at what tidal volume values ETCO2 monitoring provides reliable information.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
The patients were grouped as follows: Group 1, if the tidal volume is 4 ml/kg; Group 2, if TV=6 ml/kg; Group 3, if TV=8 ml/kg; and Group 4, if TV=10 ml/kg. It was determined how many breaths per minute (minute ventilation) would be given with tidal volume x respiratory rate=6
- The patients were ventilated with the same ventilation parameters for 30 minutes and then arterial blood gas analysis was performed. Arterial blood gas was collected at t1 for group 1, t2 for group 2, t3 for group 3, and t4 for group 4. The ETCO2 value, Peak pressure (Ppeak), Plateau pressure (Pplato), mean airway pressure (Pmean) values were recorded at the time of arterial blood gas collection. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), peak heart rate (PHR) values were evaluated. The patients with a mean arterial pressure of less than 65 mmHg were excluded from the study. Partial arterial oxygen pressure (PaO2), partial arterial carbon dioxide pressure (PaCO2), oxygen saturation (SO2) values were recorded from the arterial blood gas analysis. P (a-ET) CO2 gradient value was calculated.
The groups were compared, in each patient, under the same conditions, when the different tidal volume was applied, how the ETCO2 monitorization, PaO2 values and hence the P (a-ET) CO2 gradient changed.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Group 1 tidal volüm is 4 ml/kg |
Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter
we will increased fi02
|
| Experimental: Group 2 tidal volüm is 6 ml/kg |
Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter
we will increased fi02
|
| Experimental: Group 3 tidal volüm is 8 ml/kg |
Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter
we will increased fi02
|
| Experimental: Group 4 tidal volüm is 10 ml/kg |
Other: if the ventilation parameter caused desaturation or hypercapnia we will change the parameter
we will increased fi02
|
Outcome Measures
Primary Outcome Measures
- P (a-ET) CO2 gradient [120 minutes]
The groups were compared, in each patient, under the same conditions, when the different tidal volume was applied, how the ETCO2 monitorization, PaCO2 values and hence the P (a-ET) CO2 gradient changed.
Secondary Outcome Measures
- Partial arterial oxygen pressure (PaO2) [120 minutes]
Partial arterial oxygen pressure (PaO2) were recorded from the arterial blood gas analysis
Eligibility Criteria
Criteria
Inclusion Criteria:
American Society of Anesthesiologists (ASA) classification 1, 2 risk group
Head and neck surgery under general anesthesia lasting more than 120 minutes and who progressed normotensive.
Exclusion Criteria:
Cardiac disease
Pulmonary disease
Obese patients
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Döndü Genç Moralar | Istanbul | Istanbul, Turkey | Turkey | 34000 |
Sponsors and Collaborators
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- dondum