Altered Vestibular Perception and Transcranial Magnetic Stimulation

• Sponsor: University of Zurich (Other)
• Overall Status: Terminated
• CT.gov ID: NCT02184130
• Collaborator: (none)
• Enrollment: 7
• Location: 1
• Arm: 1
• Duration (Months): 71
• Patients Per Site Per Month: 0.1

Study Details

Study Description

Brief Summary

The long-term goal of this research is to advance our knowledge of how information from the labyrinth is brought to perception and how adaptation to vestibular imbalance influences motion sensation. Patients with vestibular disorders frequently have disabling disturbances of perception. Related to these symptoms is that large areas of the cerebral hemispheres and the cerebellum receive information from the vestibular, visual and somatosensory systems that is integrated within a vestibular cortical network into an accurate perception of spatial orientation. Interrupting the pathways that process information about the direction of gravity and angular velocity leads to impairment of the internal estimate of gravity and the perception of body motion. The strategy of this research is to use repetitive transcranial magnetic stimulation (rTMS) to produce transient focal lesions that allow study of acute loss of function within the central vestibular pathways at the very beginning of adaptation. Our underlying hypothesis is that the immediate effects of a lesion in the cerebellum will be to affect ocular motor control of vestibular reflexes and perception alike but with a cortical lesion there will be dissociation between ocular motor control and perception. This research helps to understand the mechanisms involved in the perception of vestibular information and the cerebellar influence on processing vestibular input and offers a unique opportunity to make major inroads into the understanding and eventually treatment of the often incapacitating symptoms of patients with vestibular disease

Condition or Disease	Intervention/Treatment	Phase
Verticality Perception; Self-motion Perception	Other: transcranial magnetic stimulation and motion stimuli	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 7 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Altered Vestibular Perception by Virtual Lesions of Cerebral and Cerebellar Structures Using Repetitive Transcranial Magnetic Stimulation - Implications for Human Vestibular Dysfunction
• Study Start Date: Oct 1, 2011
• Actual Primary Completion Date: Nov 1, 2016
• Actual Study Completion Date: Sep 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
Experimental: TMS	Other: transcranial magnetic stimulation and motion stimuli

Outcome Measures

Primary Outcome Measures

1. changes in verticality perception and self-motion perception after TMS (transcranial magnetic stimulation) [within 30min after TMS]

Secondary Outcome Measures

1. vestibulo-ocular reflex after TMS (transcranial magnetic stimulation) [within 30min after TMS]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 70 Years
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

1. ages 18-70

2. informed consent

Exclusion Criteria:

1. disturbed consciousness

2. other neurological or systemic disorder which can cause dementia or cognitive dysfunction

3. prior history of a major psychiatric disorder

4. history of definite stroke

5. focal lesion on MRI exam

6. use of anxiolytic, antidepressant, neuroleptic or sedative medication

7. has MRI contraindication such as pacemaker, implanted pumps, shrapnel, etc. (full MRI screening form will be filled out).

8. History of seizure or a family history of epilepsy;

9. increased intracranial pressure, such as after infarctions or trauma

10. pregnancy or possibility of being pregnant unless precluded by a negative pregnancy test

11. history of any significant head trauma.

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University Hospital Zurich, Division of Neurology	Zurich	ZH	Switzerland	8091

Sponsors and Collaborators

• University of Zurich

Investigators

• Principal Investigator: Dominik Straumann, Prof MD, University Hospital Zurich, Division of Neurology

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: University of Zurich
• ClinicalTrials.gov Identifier: NCT02184130
• Other Study ID Numbers: tms_percept_zurich
• First Posted: Jul 9, 2014
• Last Update Posted: Jul 2, 2018
• Last Verified: Jun 1, 2018

Study Results

No Results Posted as of Jul 2, 2018