Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

Sponsor

Odense University Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT00442091

Collaborator

(none)

Enrollment

Location

Arm

108

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Dandelion juice has been used in herbal medicine for at least 1000 years. Vesicular hand eczema is a rare, but difficult to treat, type of hand eczema. One case report has shown that ingestion of dandelion juice could induce a beneficial effect on this type of eczema. The purpose of this study is to test whether this effect can be retrieved in other patients.

Condition or Disease	Intervention/Treatment	Phase
Vesicular Palmoplantar Eczema Pompholyx	Drug: dandelion juice	N/A

Detailed Description

Dandelion juice has been used in herbal medicine for at least 1000 years. One case report has shown a beneficial effect of this herbal remedy on dyshidrotic hand eczema, and the purpose of this pilot study is to test whether this effect can be retrieved in other patients.

The patients are recruited from our out-patient clinic. Only patients with negative patch tests to Compositae are offered treatment with dandelion juice for 20-30 days.

Study Design

Study Type:

Interventional

Actual Enrollment :

4 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

Study Start Date :

Dec 1, 2010

Actual Primary Completion Date :

Dec 1, 2019

Actual Study Completion Date :

Dec 1, 2019

Arms and Interventions

Arm	Intervention/Treatment
Other: 10 ml of dandelion juice twice daily	Drug: dandelion juice 10 ml bid for 20-30 days

Arm

Intervention/Treatment

Other: 10 ml of dandelion juice twice daily

Drug: dandelion juice

10 ml bid for 20-30 days

Outcome Measures

Primary Outcome Measures

Improvement in dyshidrotic hand eczema in the study period assessed by HECSI score. [3-4 weeks]

Secondary Outcome Measures

Improvement in dyshidrotic eczema in the study period assessed by the patient (Visual Analog Scale). [3-4 weeks]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Adult patients with dyshidrotic eczema for at least 1 year and negative patch test reactions to Compositae (tested within the last 3 years) and normal renal and hepatic blood tests.

Exclusion Criteria:

Treatment with systemic steroids or other immunosuppressive/-modulating drugs, including UV therapy, within the last 3 months.
Pregnancy, lactation.
Compositae contact allergy.
Liver or gall bladder disease.
Abnormal renal or hepatic blood tests.