Vitamin d Levels in Children With Bacterial Meningitis
Study Details
Study Description
Brief Summary
The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.
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Detailed Description
Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis.
in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.
Study Design
Outcome Measures
Primary Outcome Measures
- vitamin d level change [change in serum vitamin d level from baseline to 28 days after initial hospitalization]
Serum vitamin d level will be detected in the first day of hospitalization and twenty-eighth day of hospitalization, no vitamin d supplementation during this time
Secondary Outcome Measures
- Clinical assessment of disease severity with Glasgow score [1 day]
Disease severity will be assessed with Glasgow score in the first day of hospitalization
- Clinical assessment of disease severity with Glasgow score [7 day]
Disease severity will be assessed with Glasgow score in the seventh day of hospitalization
- Clinical assessment of disease severity with Glasgow score [28 day]
Disease severity will be assessed with Glasgow score in the twenty-eighth day of hospitalization
- Clinical assessment of disease severity with pediatric critical illness score [1 day]
Disease severity will be assessed with pediatric critical illness score in the first day of hospitalization
- Clinical assessment of disease severity with pediatric critical illness score [7 day]
Disease severity will be assessed with pediatric critical illness score in the seventh day of hospitalization
- Clinical assessment of disease severity with pediatric critical illness score [28 day]
Disease severity will be assessed with pediatric critical illness score in the twenty-eighth day of hospitalization
- Clinical assessment of disease severity with cerebrospinal fluid examination [1 day]
Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
- Clinical assessment of disease severity with cerebrospinal fluid examination [7 day]
Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
- Clinical assessment of disease severity with cerebrospinal fluid examination [28 day]
Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
- Assessment of complications [1 day]
Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
- Assessment of complications [7 day]
Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
- Assessment of complications [28 day]
Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
Eligibility Criteria
Criteria
Inclusion Criteria:
- Probable bacterial meningitis patients: Clinical manifestation (Any person with sudden onset of fever (> 38.5 °C rectal or 38.0 °C axillary) and one of the following signs: neck stiffness, altered consciousness or other meningeal sign) with cerebrospinal fluid examination showing at least one of the following:
- turbid appearance; B.leukocytosis (> 100 cells/mm3); C.leukocytosis (10-100 cells/ mm3) AND either an elevated protein (> 100 mg/dl) or decreased glucose (< 40 mg/dl)
- Confirmed bacterial meningitis patients: A case that is laboratory-confirmed by growing (i.e. culturing) or identifying (i.e. by Gram stain or antigen detection methods) a bacterial pathogen (Hib, pneumococcus or meningococcus) in the cerebrospinal fluid or from the blood in a child with a clinical syndrome consistent with bacterial meningitis
Exclusion Criteria:
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Congenital immunodeficiency patients
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HIV patients
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Patients with corticosteroid treatment for long time
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Patients with disorders in adrenal gland and pituitary gland and hypothalamus
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Patients with tuberculosis
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Gang Liu
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 20150203