Vitamin D Status Among Infertile Women in Sweden

Vastra Gotaland Region (Other)
Overall Status
Completed ID

Study Details

Study Description

Brief Summary

The goal of this prospective cohort study is to learn about the overall and seasonal prevalence of vitamin D insufficiency and its determinants in a population of women with infertility who will go through in vitro fertilization in Sweden. The main questions it aims to answer are:

  • What is the prevalence of vitamin D insufficiency?

  • What are the determinants of this insufficiency? Participants will be asked to complete a questionnaire validated for dietary assessment of vitamin D intake and sun exposure habits and they will leave a blood sample for measurement of 25(OH)D concentration.

Researchers will compare the in vitro fertilization outcomes between women with vitamin D insufficiency and sufficiency to see if there is any difference.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Actual Enrollment :
    265 participants
    Observational Model:
    Time Perspective:
    Official Title:
    Vitamin D Status, Its Determinants and IVF Outcomes Among Infertile Women in South-Western Sweden.
    Actual Study Start Date :
    Sep 1, 2020
    Actual Primary Completion Date :
    Aug 30, 2021
    Actual Study Completion Date :
    Aug 30, 2021

    Outcome Measures

    Primary Outcome Measures

    1. Prevalence of vitamin D insufficiency [September 2020 - August 2021]

      Overall and seasonal prevalence of vitamin D insufficiency

    2. Determinants of vitamin D insufficiency [September 2020 - August 2021]

      Determinants (dietary, sun exposure habits) of vitamin D insufficiency

    Secondary Outcome Measures

    1. In vitro fertilization outcomes [September 2020 - August 2021]

      Pregnancy outcomes (biochemical pregnancy, clinical pregnancy, miscarriage, live birth) after in vitro fertilization between women with and without vitamin D insufficiency.

    Eligibility Criteria


    Ages Eligible for Study:
    18 Years to 40 Years
    Sexes Eligible for Study:
    Accepts Healthy Volunteers:
    Inclusion Criteria:
    • women aged 18-38 years, who will go through in vitro fertilization for infertility.
    Exclusion Criteria:
    • women who will go through pre-implantation genetic testing

    • women who will go through sperm- or oocyte donation treatment

    • Fertility preservation cycles

    Contacts and Locations


    Site City State Country Postal Code
    1 Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Gothenburg Sweden 24

    Sponsors and Collaborators

    • Vastra Gotaland Region


    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information


    None provided.
    Responsible Party:
    Panagiotis Tsiartas, MD, PhD, Senior Consultant, M.D., Ph.D., Vastra Gotaland Region Identifier:
    Other Study ID Numbers:
    • VitDIVF
    First Posted:
    May 8, 2023
    Last Update Posted:
    May 8, 2023
    Last Verified:
    Apr 1, 2023
    Individual Participant Data (IPD) Sharing Statement:
    Plan to Share IPD:
    Studies a U.S. FDA-regulated Drug Product:
    Studies a U.S. FDA-regulated Device Product:
    Additional relevant MeSH terms:

    Study Results

    No Results Posted as of May 8, 2023