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Volatile Versus Propofol Anesthesia in OPCAB

Sponsor
Samsung Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT02222142
Collaborator
(none)
1,080
Enrollment
1
Location
35
Duration (Months)
30.9
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.

Condition or Disease Intervention/Treatment Phase

Detailed Description

Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.

Study Design

Study Type:
Observational
Actual Enrollment :
1080 participants
Observational Model:
Case-Control
Time Perspective:
Retrospective
Official Title:
Comparison of Propofol and Isoflurane Anesthesia on Cardioprotection and Clinical Outcomes in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery : A Propensity-score Analysis
Study Start Date :
Jan 1, 2010
Actual Primary Completion Date :
Dec 1, 2012
Actual Study Completion Date :
Dec 1, 2012

Arms and Interventions

Arm Intervention/Treatment
Isoflurane group

Isoflurane inhalational anesthesia during OPCAB

Drug: Isoflurane
Comparison between isoflurane and propofol, Retrospective study
Other Names:
  • inhalational anesthetics

    		•
    Propofol group

    Total intravenous anesthesia with propofol during OPCAB

    Outcome Measures

    Primary Outcome Measures

    1. CK-MB, CRP [Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2]

      Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2

    Secondary Outcome Measures

    1. Clinical adverse outcomes [until 1 year after OPCAB]

      clinical adverse outcomes until postoperative 1 year

    Other Outcome Measures

    1. Cardioprotection and clinical adverse outcomes in diabetic patients [POD, POD 1, POD 2, one month, one year]

      primary and secondary outcome analysis in diabetic patients

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • OPCAB
    Exclusion Criteria:
    • On pump conversion

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Samsung medical center Seoul Korea, Republic of 135-710

    Sponsors and Collaborators

    • Samsung Medical Center

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Jong Hwan Lee, Assistant professor, Samsung Medical Center
    ClinicalTrials.gov Identifier:
    NCT02222142
    Other Study ID Numbers:
    • 2013-09-127
    First Posted:
    Aug 21, 2014
    Last Update Posted:
    Aug 21, 2014
    Last Verified:
    Aug 1, 2014
    Keywords provided by Jong Hwan Lee, Assistant professor, Samsung Medical Center
    Ischemic heart disease
    Off pump coronary artery bypass graft
    Isoflurane
    Propofol
    Additional relevant MeSH terms:
    Anesthetics
    Isoflurane

    Study Results

    No Results Posted as of Aug 21, 2014