Volumetric MRI Brain in Patients With Migraine

Assiut University (Other)
Overall Status
Not yet recruiting
CT.gov ID

Study Details

Study Description

Brief Summary

Assessment of the role of volumetric MRI in evaluation of different types of migraine .

Condition or Disease Intervention/Treatment Phase
  • Device: MRI

Detailed Description

Migraine is a common condition that many people experience during their lives. Evolving data reported that migraine patients have increased risk of developing silent brain lesions, such as white matter lesions and volumetric changes in both grey and white matter found on MRI .

These changes have been first investigated with CT scans which reported cerebral edema, atrophy and ischemia . With the advent of MRI and high-resolution devices, the most commonly reported structural changes were white matter lesions .

Volumetric brain MRI is the tool segments and measures volumes of the key brain structures-hippocampus, ventricles and other structures-and compares the volumes to standard normal values based on age, gender and cranial volume. This information helps assess neurological conditions and neurodegenerative diseases .

  • In migraine patients ,Volumetric MRI techniques allow better assessment of WMLs and may provide a different comprehension of structural aspects related to the migraine pathophysiology. The identification of migraineurs' brain structural alterations through non-invasive neuroimaging methods and the use of accessible and easy to-use software brings new perspectives on the assessment of the impact of this condition in central nervous system macro-architecture .

  • In previous studies, structural brain changes in migraineurs were assessed by an automated segmentation using (Free Surfer) method .

In our study, we aim to investigate these total and segmental structural changes of brain volume in migraine patients; as well as white matter lesions, in comparison to healthy controls, and in patients with episodic migraine in comparison to chronic type of migraine using another automated tissue segmentation (Vol brain) method.

Study Design

Study Type:
Anticipated Enrollment :
66 participants
Observational Model:
Time Perspective:
Official Title:
Role of Volumetric MRI Brain in Evaluation of Migraine
Anticipated Study Start Date :
Oct 10, 2023
Anticipated Primary Completion Date :
Oct 10, 2024
Anticipated Study Completion Date :
Feb 1, 2025

Arms and Interventions

Arm Intervention/Treatment

patients with migraine (migraineurs)

Device: MRI
imaging modality


healthy individuals

Device: MRI
imaging modality

Outcome Measures

Primary Outcome Measures

  1. To evaluate the role of volumetric MRI images in different types of migraine. [within first year of research]

    to stand out accuracy of MRI to detect volumetric changes which affect brain tissue in migraine

Eligibility Criteria


Ages Eligible for Study:
18 Years to 50 Years
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Inclusion Criteria:
  • Patients with different types of migraine :

  • episodic migraine without aura (MoA)

  • episodic migraine with aura (MA)

  • chronic migraine (CM).

Exclusion Criteria:
  • . History of acute myocardial infarction, ischemic or hemorrhagic stroke. . History of neurosurgery or brain trauma

  • Patients with contra-indications to MRI.

Contacts and Locations


No locations specified.

Sponsors and Collaborators

  • Assiut University


None specified.

Study Documents (Full-Text)

None provided.

More Information


None provided.
Responsible Party:
Ann Basem Fathy Kamel, resident doctor, Assiut University
ClinicalTrials.gov Identifier:
Other Study ID Numbers:
  • MRI brain in migraine
First Posted:
Oct 11, 2023
Last Update Posted:
Oct 11, 2023
Last Verified:
Oct 1, 2023
Studies a U.S. FDA-regulated Drug Product:
Studies a U.S. FDA-regulated Device Product:
Additional relevant MeSH terms:

Study Results

No Results Posted as of Oct 11, 2023