Laser Versus Cryotherapy for the Treatment of Recalcitrant Warts
Study Details
Study Description
Brief Summary
To evaluate whether laser was superior to cryotherapy for recalcitrant warts
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Patients with recalcitrant warts were randomized equally to receive laser or cryotherapy every 3 to 4 weeks, for a maximum of 4 sessions.The primary outcomes were the cure rate at 16 weeks; secondary outcomes included time to clearance of warts, patient satisfaction with the treatment and treatment-related adverse effects.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: laser treatment LP-Nd:YAG laser treatment |
Other: laser treatment
a maximum of 4 sessions, with an interval of 3 to 4 weeks
|
| Active Comparator: cryotherapy cryotherapy with liquid nitrogen |
Other: cryotherapy
a maximum of 4 sessions, with an interval of 3 to 4 weeks
|
Outcome Measures
Primary Outcome Measures
- cure rate at 16 weeks [16 weeks since the initial treatment]
A patient was considered to be cured if all warts were no longer visible and could not be palpated anymore.
Secondary Outcome Measures
- time to clearance of warts [16 weeks since the initial treatment]
The time from treatment initiation until clearance of all warts
- patient satisfaction with the treatment [16 weeks since the initial treatment]
Patient satisfaction was rated on a 5-point scale (from very happy to very unhappy)
- treatment-related adverse events [16 weeks since the initial treatment]
Some adverse effects, including pain, swelling, blisters, hemorrhagic bullae, bruising, and skin breakdown, were recorded by the patients, whereas others, including secondary bacterial infection, hyperpigmentation, hypopigmentation, and scarring were evaluated by a dermatologist
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients with HPV2/27/57-induced recalcitrant warts, including periungualor mosaic warts, common or plantar warts with a duration of longer than 1 year, and common or plantar warts previously received no more than two sessions of cryotherapy
-
Total number of warts is ≤10 .
-
Aged 18 years or older.
Exclusion Criteria:
-
Patients are currently participating in another trial for the treatment of cutaneous warts.
-
Patients have taken immunosuppressant drugs (such as oral corticosteroids) during the past three months.
-
Patients have impaired healing eg due to diabetes, vitamin A deficiency, hyperthyroidism and hypothyroidism.
-
Patients have autoimmune diseases (such as systemic lupus erythematosus, dermatomyositis, scleroderma or other diseases).
-
Patients are pregnant or ready for pregnancies or breast-feeding.
-
Patients have cold intolerance (such as cold urticaria, cryoglobulinaemia, cold agglutinin syndrome or Raynaud's syndrome).
-
Patients have local pain intolerance.
-
Patients have local hypoesthesia.
-
Patients are unable to tolerate laser or cryotherapy.
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- The 306 Hospital of People's Liberation Army
Investigators
- Principal Investigator: Shichao Lu, MD, The 306 Hospital of People's Liberation Army
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 306PLA-004