Osteocrin and Vascular Complications
Study Details
Study Description
Brief Summary
In this study, we aimed to describe the role of bone-derived factor (osteocrin) in glucose metabolism, micro and macrovascular complications in diabetic patients. Thus, further investigations of the endocrine system through bone-derived hormones may provide as new perspectives on the prediction, prevention, and treatment of diabetes mellitus.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Diabetes mellitus (DM) remained the most common metabolic disorder worldwide occupying the 8th leading cause of death.[1] Defining new predictive biomarkers in diabetes would provide a window of opportunity for preventive and/or therapeutic interventions to prevent or delay the onset of irreversible long-term micro and or macro vascular complications. Progressive micro vascular vaso-degeneration is the major factor in progression of diabetic complications and contribute greatly to the increased mortality and morbidity. [2] Where Hemodynamic-mediated vascular injury was considered as one mechanism in the pathogenesis of diabetic nephropathy. [3] Bone disorders have been drawing attention as a novel diabetic complication, and diabetes is associated with an increased risk of osteoporotic fracture [4-6]. Bone is considered as an endocrine organ that influences various organs and tissues via the secretion of multiple bone derived hormones [7-8]. These endocrinal functions are, for example, glucose homeostasis [9], appetite control [10], fat deposition [11], skeletal muscle adaptation [12], male fertility [13], and cognition [14].
Therefore, these bone-derived hormones can become useful biomarkers for predicting the incidence of diabetes and the progression of diabetic complications. Osteocrin (OSTN), a bone-derived humoral factor, is a small secreted peptide cloned from bone and muscle complementary DNA (cDNA) libraries [15]. Osteocrin (Ostn) is secreted protein produced by cells of the osteoblast lineage that shows a well conserved homology with members of the natriuretic peptide (NP) family with prohormone-like characteristics [17]. To date, the exact role of Ostn has not been elucidated.
In this study, we aimed to describe the role of bone-derived factor (osteocrin) in glucose metabolism, micro and macrovascular complications in diabetic patients. Thus, further investigations of the endocrine system through bone-derived hormones may provide as new perspectives on the prediction, prevention, and treatment of diabetes mellitus.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| 45 patients in type 1 .DM TYPE 1 DIABETES MELLITUS |
Diagnostic Test: osteocrin
laboratory routine test
Other Names:
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| and 45 patients in type 2DM TYPE 2 DIABETES MELLITUS |
Diagnostic Test: osteocrin
laboratory routine test
Other Names:
|
Outcome Measures
Primary Outcome Measures
- to test and evaluate the role of bone-derived factor (osteocrin) in glucose metabolism,in diabetic patients with risk of micro and macrovascular complications . [2 years]
Secondary Outcome Measures
- to identify bone-derived factor (osteocrin) may provide as new perspectives on the prediction, prevention, and treatment of diabetes mellitus [1 year]
Eligibility Criteria
Criteria
Inclusion Criteria:
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Cases of the study will select randomly, based on inclusion criteria that included
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Patients were diagnosed with diabetes mellitus according to American Diabetes Association
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Age range 20-70 years
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No apparent vascular abnormalities and Acute complications
Exclusion Criteria:
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Patients are excluded for participation in the study if
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Patients had past history of cardiovascular events (heart failure or history of coronary artery disease),
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infections,
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aacute diabetic complications,
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diabetic patients on regular hemodialysis .
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acute illness, malignancy, or pregnancy.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | walaa soliman Hussien | Assiut | Egypt |
Sponsors and Collaborators
- Assiut University
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Nephrologist