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White Matter Integrity According to BDNF Genotype After Stroke

Sponsor
Samsung Medical Center (Other)
Overall Status
Completed
CT.gov ID
NCT03647787
Collaborator
(none)
58
Enrollment
1
Location
10.3
Actual Duration (Months)
5.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The aim of this study was to investigate differential plastic changes of fractional anisotropy (FA) in the corticospinal tract (CST), the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv) and the corpus callosum (CC) from 2 weeks to 3 months after stroke according to BDNF genotype.

Condition or Disease Intervention/Treatment Phase
  • Other: observational study

Detailed Description

The aims of this study were to investigate plastic changes in the fractional anisotropy (FA) of three motor-related white matter fibers according to the BDNF genotype from 2 weeks to 3 months after stroke onset; one is a the majority of fibers from M1 to medullary oblongata (CST), another is the intrahemispheric connection from M1 to ventral premotor cortex (M1PMv), and the other is the interhemispheric connection between bilateral M1s (CC). There were also to investigate the relationships between motor impairment and tract-related FA of white matter tracts in each BDNF genotype

Study Design

Study Type:
Observational
Actual Enrollment :
58 participants
Observational Model:
Case-Only
Time Perspective:
Retrospective
Official Title:
Changes of White Matter Integrity According to BDNF Genotype During Motor Recovery After Stroke
Actual Study Start Date :
May 25, 2018
Actual Primary Completion Date :
Apr 5, 2019
Actual Study Completion Date :
Apr 5, 2019

Outcome Measures

Primary Outcome Measures

  1. Fractional anisotropy [2 weeks to 3 months after stroke onset]

    changes of fractional anisotropy (FA) in the corticospinal tract (CST)

Secondary Outcome Measures

  1. Fractional anisotropy [2 weeks to 3 months after stroke onset]

    changes of fractional anisotropy (FA) in the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv)

  2. Fractional anisotropy [2 weeks to 3 months after stroke onset]

    changes of fractional anisotropy (FA) in the corpus callosum (CC)

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 80 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
  • diagnosed with first-ever hemispheric ischemic infarction with damage to the supratentorial area confirmed by brain MRI within 2 weeks after stroke onset
Exclusion Criteria:
  • any clinically significant or unstable medical disorder or neuropsychiatric comorbidity

Contacts and Locations

Locations

Site City State Country Postal Code
1 Samsung Medical Center Seoul Gangnam-gu Korea, Republic of 06351

Sponsors and Collaborators

  • Samsung Medical Center

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT03647787
Other Study ID Numbers:
  • 2018-04-146
First Posted:
Aug 27, 2018
Last Update Posted:
Sep 19, 2019
Last Verified:
Sep 1, 2018
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Stroke

Study Results

No Results Posted as of Sep 19, 2019