Remineralizing Potential of Biomimetic Scaffolds on Enamel White Spot Lesions
Study Details
Study Description
Brief Summary
The modern concept in caries treatment focuses on the non-invasive approach and on the biomimetic remineralization of early non-cavitated white spot carious lesions. Recently developed biomimetic scaffolds attempt to remineralize the dental tissues and are more regenerative than reparative.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Group I
|
Other: Curodont repair Self- assembling peptide P11-4
The labial surface of each tooth in both arches from central to the first premolar on both sides will be treated by Curodont
|
| Experimental: Group II
|
Other: Ph-chi phosphorylated - nano-chitosan
The labial surface of each tooth in both arches from central to the first premolar on both sides will be treated by Ph-chi phosphorylated - nano-chitosan
|
| Active Comparator: Group III
|
Other: CCP-ACP " +ve control " Casein phosphopeptide amorphous calcium phosphate
The labial surface of each tooth in both arches from central to the first premolar on both sides will be treated by CCP-ACP
|
Outcome Measures
Primary Outcome Measures
- Change in DIAGNOdent values [Baseline, 1 month, 3 months , 6 months, 9 months, 12 months]
The DIAGNOdent uses laser fluorescence to aid in the detection of caries within the tooth structure.
- change in ICDAS scores [Baseline, 1 month, 3 months , 6 months, 9 months, 12 months]
Code Description 0: Sound tooth surface: No evidence of caries after 5 sec air drying First visual change in enamel: Opacity or discoloration (white or brown) is visible at the entrance to the pit or fissure seen after prolonged air drying Distinct visual change in enamel visible when wet, lesion must be visible when dry Localized enamel breakdown (without clinical visual signs of dentinal involvement) seen when wet and after prolonged drying Underlying dark shadow from dentine Distinct cavity with visible dentine Extensive (more than half the surface) distinct cavity with visible dentine
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Patients who at least have 1 white spot lesion.
-
No systemic diseases or taking any medication affecting salivary flow.
-
Patients with good oral hygiene measures.
-
Patients with moderate caries risk assessment.
-
Post orthodontic WSLs with International Caries Detection and Assessment System (ICDAS
- scoring criteria (1-2).
Exclusion Criteria:
-
Participant in another trial.
-
Developmental non carious lesion (enamel hypoplasia and dental fluorosis).
-
Presence of abnormal oral disease, or medically compromised patients.
-
Participants who had evidence of reduced salivary flow or significant tooth wear.
-
Allergy to milk products or other drug allergies.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Alexandria Faculty of Dentistry | Alexandria | Egypt |
Sponsors and Collaborators
- Hams Hamed Abdelrahman
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- biomimetic scaffolds _2022