Whole Egg Intake and Choline Concentration in the Aging Brain

Sponsor

University of Kansas Medical Center (Other)

Overall Status

Recruiting

CT.gov ID

NCT05021211

Collaborator

Egg Nutrition Center (Other)

Enrollment

Location

Anticipated Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status. Additionally, researchers also plan to see if there is a relationship between brain choline status and cognition.

Condition or Disease	Intervention/Treatment	Phase
Alzheimer Disease

Detailed Description

Participants will come to the research center for 2 different visits. Visit 1 will include anthropometric measurements, surveys, and a cognitive test. Approximately 7-10 days after visit 1, participants will come back to the research center for visit 2. At visit 2, participants will return surveys and a MRI scan will be performed to measure brain choline status. Potential participants need to be located within the Kansas City metro area.

Study Design

Study Type:

Observational

Anticipated Enrollment :

60 participants

Observational Model:

Ecologic or Community

Time Perspective:

Cross-Sectional

Official Title:

Whole Egg Intake and Choline Concentration in the Aging Brain

Actual Study Start Date :

Jun 1, 2021

Anticipated Primary Completion Date :

Jun 1, 2023

Anticipated Study Completion Date :

Dec 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
Low Egg Consumers Participants who consume fewer than 1 whole egg per week
Moderate Egg Consumers Participants who consume 5-9 whole eggs per week
High Egg Consumers Participants who consumes great than or equal to 14 whole eggs per week

Outcome Measures

Primary Outcome Measures

Association Between Whole Egg Intake and Cerebral Choline [Baseline]
The investigators will recruit a variety of whole egg consumers. Egg consumption will be validated with a 7-day food record 1 week before the MRI. Cerebral choline levels are measured by magnetic resonance spectroscopy (MRS)
Association Between Cerebral Choline and Cognition [Baseline]
The investigators will test the association between cerebral choline as measured by MRS and cognition. Cognition will be measured by the NIH ToolBox cognitive battery.

Eligibility Criteria

Criteria

Ages Eligible for Study:

60 Years to 85 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Aged between 60 - 85 years of age
Good general health with no concomitant diseases
Cognitively normal as defined as Mini-mental state examination (MMSE) score ≥ 25
BMI range: 20 - 40 kg/m2

Exclusion Criteria:

Presence of central neurological disease (e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer's, Parkinson's)
Prior major head trauma with loss of consciousness
Presence of active unstable and life-threatening illness (e.g., cancer)
Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score > 6)
Presence of diabetes mellitus or use of anti-diabetic agents
Use of psychoactive and investigational medications
Use of hormone replacement therapy
Tobacco smokers
Subjects with MRI contraindications