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Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Sponsor
Hadassah Medical Organization (Other)
Overall Status
Completed
CT.gov ID
NCT00382369
Collaborator
(none)
11
Enrollment
1
Location
6.9
Actual Duration (Months)
1.6
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    11 participants
    Observational Model:
    Family-Based
    Time Perspective:
    Prospective
    Official Title:
    Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis
    Actual Study Start Date :
    Jun 1, 2008
    Actual Primary Completion Date :
    Nov 17, 2008
    Actual Study Completion Date :
    Dec 29, 2008

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      10 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • members of families suffering of familial vocal cord paralysis
      Exclusion Criteria:
      • none

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Hadassah-Hebrew University Medical Center, Mt Scopus Jerusalem Israel 24035

      Sponsors and Collaborators

      • Hadassah Medical Organization

      Investigators

      • Study Director: Eitan Kerem, MD, Hadassah MO
      • Principal Investigator: Batsheva Kerem, PhD, Hebrew University Jerusalem

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      Responsible Party:
      Kerem Eithan, Professor, Hadassah Medical Organization
      ClinicalTrials.gov Identifier:
      NCT00382369
      Other Study ID Numbers:
      • VOCALCORD-HMO-CTIL
      First Posted:
      Sep 29, 2006
      Last Update Posted:
      Feb 27, 2017
      Last Verified:
      Feb 1, 2017
      Individual Participant Data (IPD) Sharing Statement:
      No
      Plan to Share IPD:
      No
      Keywords provided by Kerem Eithan, Professor, Hadassah Medical Organization
      familial vocal cord paralysis
      genetic screening
      Additional relevant MeSH terms:
      Vocal Cord Paralysis
      Paralysis

      Study Results

      No Results Posted as of Feb 27, 2017