Resistance Training and Sex Hormone Concentrations During the Menstrual Cycle

Sponsor
Southern Illinois University Edwardsville (Other)
Overall Status
Unknown status
CT.gov ID
NCT04163380
Collaborator
(none)
25
1
4
25
1

Study Details

Study Description

Brief Summary

Although there are numerous studies showing effects of aerobic training on sex hormone concentrations, research analyzing the fluctuation of sex hormones in response to resistance training (RT) is lacking. The objective of this project is to analyze estradiol (E2) and progesterone (P4) responses to an acute resistance training session throughout different phases of the menstrual cycle. This proposed research has strong implications for exercise prescription and for women in general, but more importantly will allow exercise physiologists, coaches, personal trainers, or nutritionists optimize exercise programming around women's menstrual cycle.

Condition or Disease Intervention/Treatment Phase
  • Behavioral: Resistance Training
N/A

Study Design

Study Type:
Interventional
Anticipated Enrollment :
25 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Intervention Model Description:
Participants will be blocked (four participants by block) and then randomized to start in one of the four menstrual cycle phases (EFP, LFP, ELP, or LLP). Their will be complete once they have gone through the four phases.Participants will be blocked (four participants by block) and then randomized to start in one of the four menstrual cycle phases (EFP, LFP, ELP, or LLP). Their will be complete once they have gone through the four phases.
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Acute Effects of Resistance Training on Sex Hormone Concentrations on Different Phases of the Menstrual Cycle
Actual Study Start Date :
Nov 1, 2019
Anticipated Primary Completion Date :
Dec 1, 2021
Anticipated Study Completion Date :
Dec 1, 2021

Arms and Interventions

Arm Intervention/Treatment
Experimental: Early Follicular Phase (EFP)

Behavioral: Resistance Training
Participants will exercise at the mid-point of each menstrual cycle phase (EFP- day 4, LFP- day 11, ELP- day 18 and LLP- day 25 for a 28 day menstrual cycle). Training will consist of a warm up. Intensity will be set at 70% of 1RM, and the circuit training will include 7 strength exercises: leg press, rows, back squat, weighted crunches, deadlifts, bench press, and weighted squat jumps. The participant will perform 3 sets f 10 repetitions with 30 seconds of rest

Experimental: Late Follicular Phase (LFP)

Behavioral: Resistance Training
Participants will exercise at the mid-point of each menstrual cycle phase (EFP- day 4, LFP- day 11, ELP- day 18 and LLP- day 25 for a 28 day menstrual cycle). Training will consist of a warm up. Intensity will be set at 70% of 1RM, and the circuit training will include 7 strength exercises: leg press, rows, back squat, weighted crunches, deadlifts, bench press, and weighted squat jumps. The participant will perform 3 sets f 10 repetitions with 30 seconds of rest

Experimental: Early Luteal Phase (ELP)

Behavioral: Resistance Training
Participants will exercise at the mid-point of each menstrual cycle phase (EFP- day 4, LFP- day 11, ELP- day 18 and LLP- day 25 for a 28 day menstrual cycle). Training will consist of a warm up. Intensity will be set at 70% of 1RM, and the circuit training will include 7 strength exercises: leg press, rows, back squat, weighted crunches, deadlifts, bench press, and weighted squat jumps. The participant will perform 3 sets f 10 repetitions with 30 seconds of rest

Experimental: Late Luteal Phase (LLP)

Behavioral: Resistance Training
Participants will exercise at the mid-point of each menstrual cycle phase (EFP- day 4, LFP- day 11, ELP- day 18 and LLP- day 25 for a 28 day menstrual cycle). Training will consist of a warm up. Intensity will be set at 70% of 1RM, and the circuit training will include 7 strength exercises: leg press, rows, back squat, weighted crunches, deadlifts, bench press, and weighted squat jumps. The participant will perform 3 sets f 10 repetitions with 30 seconds of rest

Outcome Measures

Primary Outcome Measures

  1. Change in estrogen concentrations [through study completion, an average of 5 weeks]

    Estrogen concentrations will be obtained from blood samples assessed using through ELISA kits

  2. Change in progesterone concentrations [through study completion, an average of 5 weeks]

    Progesterone concentrations will be obtained from blood samples assessed using through ELISA kits

Secondary Outcome Measures

  1. Lean body mass (kg) [At baseline: 1 assessment point]

    Lean body mass (kg) will be assessed through Dual-energy X-ray Absorptiometry

  2. Fat mass (kg) [At baseline: 1 assessment point]

    Fat mass (kg) will be assessed through Dual-energy X-ray Absorptiometry

  3. Relative body fat (%) [At baseline: 1 assessment point]

    Relative body fat (%) will be assessed through Dual-energy X-ray Absorptiometry

  4. Skeletal muscle mass (kg) [At baseline: 1 assessment point]

    Skeletal muscle mass (kg) will be estimated using Dual-energy X-ray Absorptiometry values

  5. Cardiorespiratory Fitness [At baseline: 1 assessment point]

    Cardiorespiratory Fitness will be assessed with a cardiopulmonary exercise test using the Bruce protocol

  6. Strength in Bench Press [At baseline: 1 assessment point]

    Maximal strength bench press will be assessed using one repetition maximum test

  7. Strength in Leg Press [At baseline: 1 assessment point]

    Maximal strength in leg press will be assessed using one repetition maximum test

  8. Changes in diet [through study completion, an average of 5 weeks]

    Diet will be assessed using the a 24h dietary recall

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 45 Years
Sexes Eligible for Study:
Female
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Eumenorrheic females

  • Age 18-45 years old

  • BMI of 18.5-34.99 kg/m2

Exclusion Criteria:
  • Practice exercise more than 2 days/week in the last 3 months.

  • Cardiovascular, metabolic, pulmonary or muscular-skeletal condition

  • Taking medications that affect metabolism (e.g. oral contraceptives)

  • Irregular menstrual cycles

Contacts and Locations

Locations

Site City State Country Postal Code
1 Southern Illinois University Edwardsville Edwardsville Illinois United States 62026

Sponsors and Collaborators

  • Southern Illinois University Edwardsville

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Southern Illinois University Edwardsville
ClinicalTrials.gov Identifier:
NCT04163380
Other Study ID Numbers:
  • 111B
First Posted:
Nov 14, 2019
Last Update Posted:
Feb 18, 2020
Last Verified:
May 1, 2019
Individual Participant Data (IPD) Sharing Statement:
No
Plan to Share IPD:
No
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Southern Illinois University Edwardsville

Study Results

No Results Posted as of Feb 18, 2020