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acalabrutinib

Acalabrutinib is a drug used to treat Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Small Lymphocytic Lymphoma, and other conditions. Acalabrutinib is being actively studied in 66 studies and prior, has been studied in 13.

Top SponsorsTop SitesTop Investigators
Acerta Pharma BVResearch SiteAustin I Kim
AstraZenecaM D Anderson Cancer CenterCarsten Utoft Niemann
M.D. Anderson Cancer CenterBeth Israel Deaconess Medical CenterCraig Moskowitz
STUDY
CONDITIONS
INTERVENTIONS
LOCATIONS
LAST UPDATED
U
Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma
Not yet recruiting
  • Mantle Cell Lymphoma
  • (no location specified)
2021-08-04
Aug 4, 2021
U
LCCC1841: A Phase 2 Trial of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas
Recruiting
  • Lymphoma
  • Chapel Hill, North Carolina
  • +1 more
2021-11-12
Nov 12, 2021
S
Acalabrutinib Plus RICE for Relapsed/Refractory DLBCL
Recruiting
  • Diffuse Large B Cell Lymphoma
  • Seattle, Washington
    Swedish Cancer Institute
2021-03-01
Mar 1, 2021
W
Early Intervention With Acalabrutinib in Patients With High Risk CLL
Not yet recruiting
  • Chronic Lymphocytic Leukemia
  • CLL/SLL
  • Acalabrutinib
  • New York, New York
    Weill Cornell Medicine
2021-11-20
Nov 20, 2021
A
A Study to Evaluate the Effect of Gastric pH on Acalabrutinib Pharmacokinetics (PK) in Healthy Adult Participants - 2016
Completed
  • Healthy Volunteers
  • Tempe, Arizona
    Celerion
2021-06-02
Jun 2, 2021
D
Acalabrutinib in CNSL
Not yet recruiting
  • Central Nervous System Lymphoma
  • +2 more
  • Acalabrutinib
  • Boston, Massachusetts
  • +1 more
2021-06-07
Jun 7, 2021
U
Acalabrutinib With R-CHOP in Previously Untreated Mantle Cell Lymphoma
Recruiting
  • Mantle Cell Lymphoma
  • Acalabrutinib
  • R-CHOP chemotherapy
  • Vancouver, British Columbia, Canada
  • +2 more
2021-06-21
Jun 21, 2021
A
A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants - 2020
Completed
  • Infectious Disease
  • Anaheim, California
    Research Site
2020-10-29
Oct 29, 2020
F
Acalabrutinib for the Treatment of Chronic Graft Versus Host Disease
Recruiting
  • Recurrent Moderate-Severe Chronic Graft Versus Host Disease
  • Hematopoietic and Lymphoid Cell Neoplasm
  • Acalabrutinib
  • Questionnaire Administration
  • Tampa, Florida
  • +3 more
2021-12-22
Dec 22, 2021
A
Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite - 2019
Completed
Has Results
  • Hepatic Impairment
  • +2 more
  • acalabrutinib
  • Miami, Florida
  • +2 more
2021-08-16
Aug 16, 2021
A
A Study to Evaluate the Effect of Pharmacokinetics (PK) of Acalabrutinib and Its Active Metabolite (ACP-5862) When Administered Alone and With Moderate CYP3A4 Inhibitors Fluconazole or Isavuconazole in Healthy Adult Participants - 2020
Completed
  • Healthy Volunteers
  • Acalabrutinib
  • +2 more
  • Tempe, Arizona
    Celerion
2021-11-17
Nov 17, 2021
M
Acalabrutinib and Obinutuzumab for the Treatment of Chronic Lymphocytic Leukemia
Recruiting
  • Chronic Lymphocytic Leukemia
  • Small Lymphocytic Lymphoma
  • Acalabrutinib
  • Obinutuzumab
  • Houston, Texas
    M D Anderson Cancer Center
2021-11-18
Nov 18, 2021
M
Acalabrutinib for the Treatment of Ibrutinib-Intolerant Mantle Cell Lymphoma
Recruiting
  • Mantle Cell Lymphoma
  • Acalabrutinib
  • Houston, Texas
    M D Anderson Cancer Center
2020-12-04
Dec 4, 2020
C
Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia
Recruiting
  • Autoimmune Hemolytic Anemia
  • +3 more
  • Acalabrutinib
  • Duarte, California
    City of Hope Medical Center
2021-08-10
Aug 10, 2021
F
Acalabrutinib in Combination With Venetoclax for the Treatment of Refractory or Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Not yet recruiting
  • Recurrent Chronic Lymphocytic Leukemia
  • +3 more
  • Seattle, Washington
    Fred Hutch/University of Washington Cancer Consortium
2021-12-23
Dec 23, 2021
S
Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia
Recruiting
  • Waldenstrom Macroglobulinemia
  • Acalabrutinib
  • +2 more
  • Vancouver, British Columbia, Canada
  • +3 more
2021-07-23
Jul 23, 2021
J
Preventing Anaphylaxis With Acalabrutinib
Recruiting
  • Food Allergy
  • Food Allergy Peanut
  • Acalabrutinib
  • Baltimore, Maryland
    Johns Hopkins Bayview Medical Center
2021-12-30
Dec 30, 2021
W
Acalabrutinib and Durvalumab in Primary and Secondary Central Nervous System Lymphoma
Recruiting
  • Primary Central Nervous System Lymphoma
  • Secondary Central Nervous System Lymphoma
  • Saint Louis, Missouri
    Washington University School of Medicine
2021-05-12
May 12, 2021
M
Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Recruiting
  • Chronic Lymphocytic Leukemia
  • Small Lymphocytic Lymphoma
  • Acalabrutinib
  • +4 more
  • Scottsdale, Arizona
  • +2 more
2021-08-19
Aug 19, 2021
N
Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma
Recruiting
  • Non-Hodgkin's Lymphoma
  • +3 more
  • Bethesda, Maryland
    National Institutes of Health Clinical Center
2021-12-30
Dec 30, 2021
N
Acalabrutinib and Duvelisib for the Treatment of Relapsed/Refractory Indolent Non-Hodgkin Lymphoma
Recruiting
  • Recurrent Follicular Lymphoma
  • +8 more
  • Columbus, Ohio
    Ohio State University Comprehensive Cancer Center
2021-12-16
Dec 16, 2021
M
Venetoclax-Obinutuzumab +/- Acalabrutinib in R/R CLL
Recruiting
  • Chronic Lymphocytic Leukemia
  • Small Lymphocytic Lymphoma
  • Boston, Massachusetts
  • +2 more
2021-08-09
Aug 9, 2021
S
Treatment With Acalabrutinib Post Blood or Marrow Transplantation in Subjects With Mantle Cell Lymphoma
Recruiting
  • Mantle Cell Lymphoma
  • Acalabrutinib
  • Denver, Colorado
  • +3 more
2021-05-20
May 20, 2021
W
Acalabrutinib With Bendamustine / Rituximab Followed by Cytarabine / Rituximab for Untreated Mantle Cell Lymphoma
Active, not recruiting
Has Results
  • Mantle Cell Lymphoma
  • Saint Louis, Missouri
    Washington University School of Medicine
2021-01-30
Jan 30, 2021
U
Acalabrutinib and High Frequency Low Dose Subcutaneous Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma
Recruiting
  • Chronic Lymphocytic Leukemia (CLL)
  • Small Lymphocytic Lymphoma (SLL)
  • Rochester, New York
    University of Rochester
2021-02-02
Feb 2, 2021