Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

Sponsor

US Department of Veterans Affairs (U.S. Fed)

Overall Status

Completed

CT.gov ID

NCT00108407

Collaborator

(none)

Location

Arms

Study Details

Study Description

Brief Summary

The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use disorders.

Condition or Disease	Intervention/Treatment	Phase
Alcohol Abuse Cannabis Abuse Major Depressive Disorder Substance-Related Disorders	Behavioral: Integrated Cognitive Behavioral Therapy Behavioral: Twelve Step Facilitation Therapy	N/A

Detailed Description

Depression is the most frequent co-occuring mental health disorder among adults with substance use disorders, and such comorbidity is often associated with poorer treatment outcomes. Although there is an urgent need for effective treatments specific for dual-diagnosis adults, few studies have been conducted to address this need.

Comparison: This study will compare substance use and depression symptoms of individuals in two different psychotherapy groups: Integrated Cognitive Behavioral Therapy and Twelve Step Facilitation Therapy. Symptoms and substance use will be compared during the active treatment phase (24 weeks) and for one year following the end of the active treatment.

Study Design

Study Type:

Interventional

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

None (Open Label)

Official Title:

Integrated CBT for Substance Use and Depressive Disorders

Study Start Date :

Oct 1, 2004

Arms and Interventions

Arm	Intervention/Treatment
Experimental: 1 Integrated Cognitive Behavioral Therapy	Behavioral: Integrated Cognitive Behavioral Therapy
Experimental: 2 Twelve Step Facilitation Therapy	Behavioral: Twelve Step Facilitation Therapy

Arm

Intervention/Treatment

Experimental: 1

Integrated Cognitive Behavioral Therapy

Behavioral: Integrated Cognitive Behavioral Therapy

Experimental: 2

Twelve Step Facilitation Therapy

Behavioral: Twelve Step Facilitation Therapy

Outcome Measures

Primary Outcome Measures

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 70 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Individuals diagnosed with one or more substance use disorders (alcohol, cannabis, and or stimulant abuse/dependence) and an independent co-occurring depressive disorder (major depression or dysthymia) will be included.

Exclusion Criteria:

Individuals with substance induced mood disorders and individuals experiencing persistent psychotic symptoms.
Those with life threatening or unstable medical illness, neurological disorders, or inability to read will be excluded.
Individuals currently prescribed steroids, disulfiram, or long acting benzodiazepines will be excluded.