Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma
Sponsor
National Cancer Institute (NCI) (NIH)
Overall Status
Recruiting
CT.gov ID
NCT03907488
Collaborator
(none)
987
732
2
55.4
1.3
0
Study Details
Study Description
Brief Summary
This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Brentuximab vedotin is a monoclonal antibody, brentuximab, linked to a toxic agent called vedotin. Brentuximab attaches to cancer cells in a targeted way and delivers vedotin to kill them. Chemotherapy drugs, such as doxorubicin, vinblastine, and dacarbazine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The addition of nivolumab or brentuximab vedotin to combination chemotherapy may shrink the cancer or extend the time without disease symptoms coming back.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
|
Phase 3 |
Detailed Description
PRIMARY OBJECTIVE:
- To compare the progression-free survival (PFS) in patients with newly diagnosed advanced stage classical Hodgkin lymphoma randomized to N-AVD (nivolumab, doxorubicin hydrochloride [doxorubicin], vinblastine sulfate [vinblastine], dacarbazine) versus that obtained with BV-AVD (brentuximab vedotin, doxorubicin, vinblastine, dacarbazine).
SECONDARY OBJECTIVES:
-
To compare overall survival (OS) in patients randomized to N-AVD versus BV-AVD.
-
To compare event-free survival (EFS) in patients randomized to N-AVD versus BV-AVD.
-
To compare the metabolic complete response (CR) rate at the end of treatment in patients randomized to N-AVD versus BV-AVD.
-
To compare the physician-reported treatment-related adverse event rates between arms stratified by age groups.
-
To compare patient-reported symptoms using selected Patient Reported Outcome Common Toxicity Criteria for Adverse Events (PRO-CTCAE) items between arms stratified by age groups.
-
To compare the safety and tolerability of N-AVD versus that of BV-AVD.
QUALITY OF LIFE OBJECTIVE:
- To compare between arms patient-reported fatigue, neuropathy and health-related quality of life over time (baseline, beginning of cycle 3, 4-8 weeks after the last dose of protocol therapy [following last dose of study drug or radiation therapy, whichever is later], and 1 and 3 years after randomization) using the Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue, the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx), and the PROMIS Global, respectively.
BANKING OBJECTIVES:
- To bank specimens for future correlative studies. II. To bank positron emission tomography (PET)-computed tomography (CT) images for future correlative studies.
OUTLINE: Patients are randomized to 1 of 2 arms.
ARM I: Patients receive doxorubicin hydrochloride intravenously (IV), vinblastine sulfate IV, dacarbazine IV, and nivolumab IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim subcutaneously (SC) on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician.
ARM II: Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and brentuximab vedotin IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician.
After completion of study treatment and prior to disease progression, patients are followed up every 3 months for the first year, every 6 months for years 2 and 3, then annually until 10 years after registration. Patients are followed up at the time of progression and then annually until 10 years after registration. Patients who receive radiation therapy are followed up at 8-12 weeks after completion of radiation therapy.
Study Design
Study Type:
Interventional
Anticipated Enrollment
:
987 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
A Phase III, Randomized Study of Nivolumab (Opdivo) Plus AVD or Brentuximab Vedotin (Adcetris) Plus AVD in Patients (Age >/= 12 Years) With Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma
Actual Study Start Date
:
Jul 19, 2019
Anticipated Primary Completion Date
:
Mar 1, 2024
Anticipated Study Completion Date
:
Mar 1, 2024
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Arm I (chemotherapy, nivolumab, radiation) Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and nivolumab IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. |
Drug: Dacarbazine
Given IV
Other Names:
Drug: Doxorubicin Hydrochloride
Given IV
Other Names:
Biological: Filgrastim
Given SC or IV
Other Names:
Biological: Nivolumab
Given IV
Other Names:
Biological: Pegfilgrastim
Given SC
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Other: Questionnaire Administration
Ancillary studies
Radiation: Radiation Therapy
Receive radiation therapy
Other Names:
Drug: Vinblastine Sulfate
Given IV
Other Names:
|
| Experimental: Arm II (chemotherapy, brentuximab vedotin, radiation) Patients receive doxorubicin hydrochloride IV, vinblastine sulfate IV, dacarbazine IV, and brentuximab vedotin IV over 30 minutes on days 1 and 15. Patients may receive pegfilgrastim SC on days 2 and 16, or filgrastim SC or IV on days 6-10 and 21-25. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. After completion of cycle 6, patients may receive radiation therapy 5 days per week for approximately 4 weeks at the discretion of the treating physician. |
Drug: Brentuximab Vedotin
Given IV
Other Names:
Drug: Dacarbazine
Given IV
Other Names:
Drug: Doxorubicin Hydrochloride
Given IV
Other Names:
Biological: Filgrastim
Given SC or IV
Other Names:
Biological: Pegfilgrastim
Given SC
Other Names:
Other: Quality-of-Life Assessment
Ancillary studies
Other Names:
Other: Questionnaire Administration
Ancillary studies
Radiation: Radiation Therapy
Receive radiation therapy
Other Names:
Drug: Vinblastine Sulfate
Given IV
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Progression free survival (PFS) [From date of registration to date of first observation of progressive disease according to the 2014 Lugano classification, or death due to any cause, assessed at 2 years]
Will test the null hypothesis (HR=1) for PFS using stratified log-rank test with a one-sided alpha of 0.021. The analysis will be based on modified intent-to-treat and will include all eligible patients as randomized regardless of treatment received. The one-sided alpha of .021 will control of the overall type-one error of the study (including the 2 interim superiority analyses) to be less than .025.
Secondary Outcome Measures
- Overall survival [2 years]
- Event-free survival (EFS) [From date of registration to date of first occurrence of EFS event, assessed at 2 years]
Will be estimated using Kaplan-Meier method and compared between treatment arms using cox regression model.
- Metabolic complete response rate [Up to 10 years]
Defined using 2014 Lugano classification.
- Incidence of adverse events [Up to 10 years]
Toxicity will be evaluated using Common Terminology Criteria of Adverse Events (CTCAE) version 5 items. Treatment-related toxicities between arms will be compared using Fisher's exact test stratified by age groups. Targeted patient-reported toxicities also will be collected at each time point using the Patient Reported Outcome (PRO)-CTCAE for patients 18 years and older and from youth 12-17 years, using the Pediatric (Ped) PRO-CTCAE.
Eligibility Criteria
Criteria
Ages Eligible for Study:
12 Years
and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:
-
All patients must have histologically confirmed newly diagnosed, previously untreated stage III or IV classical Hodgkin lymphoma (nodular sclerosing, mixed cellularity, lymphocyte-rich, or lymphocyte-depleted, or not otherwise specified [NOS]). Nodular lymphocyte predominant Hodgkin lymphoma is not eligible.
-
Patients must have bidimensionally measurable disease (at least one lesion with longest diameter >= 1.5 cm) documented on the Lymphoma Baseline Tumor Assessment Form in Rave.
-
Patients must have a whole body or limited whole body PET-CT scan performed within 42 days prior to registration. (A contrast-enhanced [diagnostic] CT, MRI or MR-PET is acceptable in event that PET-CT is contra-indicated, however if it is later possible to administer a PET-CT, then PET-CT is strongly preferred for the interim scan (after cycle 2) (if performed) and the EOT assessment. Otherwise, if PET-CT is not subsequently possible, then the same modality as baseline must be used throughout the trial.) NOTE: All images from PET-CT, CT, MRI or MR-PET scans performed as standard of care to assess disease (within 42 days prior to registration) must be submitted and associated radiology reports must be submitted.
-
Patients must not have received any prior chemotherapy, radiation, or antibody-based treatment for classical Hodgkin lymphoma. Steroid pre-treatment is permitted.
-
Patients must not have had prior solid organ transplant.
-
Patients must not have had prior allogeneic stem cell transplantation.
-
Patients must not have received a live vaccine within 30 days prior to planned day 1 of protocol therapy (e.g. measles, mumps, rubella, varicella, yellow fever, rabies, Bacillus Calmette-Guerin [BCG], oral polio vaccine, and oral typhoid).
-
At registration, investigator must declare intent-to-treat with residual PET radiation therapy (residual PET RT- RPRT) to be administered after patient completes 6 cycles of therapy if, after end of treatment, the patient meets criteria specified for receiving RT). Patients will be stratified by investigator's intent-to-treat with residual PET RT.
-
All pediatric patients (< 18 years of age) will be considered intent-to-treat with Residual PET RT at time of registration.
-
Patients must have a performance status corresponding to Zubrod scores of 0, 1 or 2. Use Lansky for patients =< 17 years of age. *The conversion of the Lansky to Eastern Cooperative Oncology Group (ECOG) scales is intended for National Cancer Institute (NCI) reporting purposes only.
-
Adults (age 18 or older): Creatinine clearance >= 30 mL/min, as estimated by the Cockcroft and Gault formula. The creatinine value used in the calculation must have been obtained within 28 days prior to registration. Estimated creatinine clearance is based on actual body weight.
Pediatric Patients (age 12-17), the following must have been obtained within 14 days prior to registration:
-
Measured or calculated creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 ml/min/1.73 m^2, or
-
Serum creatinine =< 1.5 x institutional upper limit of normal (IULN), or a serum creatinine (SCr) based on age/gender as follows:
-
Age < 13 maximum serum creatinine: Male 1.2 mg/dL; Female 1.2 mg/dL
-
Age 13 to < 16 maximum serum creatinine: Male 1.5 mg/dL; Female 1.4 mg/dL
-
Age 16-17 maximum serum creatinine: Male 1.7 mg/dL; Female 1.4 mg/dL
-
Total bilirubin =< 2 x IULN (must be documented within 28 days prior to registration for adults [age 18 or older]; must be documented within 14 days prior to registration for pediatric patients [age 12-17]).
-
Unless due to Gilbert's disease, lymphomatous involvement of liver or vanishing bile duct syndrome
-
Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x IULN (must be documented within 28 days prior to registration for adults [age 18 or older]; must be documented within 14 days prior to registration for pediatric patients [age 12-17]).
-
Unless due to Gilbert's disease, lymphomatous involvement of liver or vanishing bile duct syndrome
-
Patients must have an echocardiogram (ECHO), multigated acquisition (MUGA), or functional cardiac imaging scan with a left ventricular ejection (LVEF) fraction
= 50% or a shortening fraction of >= 27%. For all patients, the ECHO, MUGA, or functional cardiac imaging scan must be performed within 42 days prior to registration.
-
Patients with known human immunodeficiency virus (HIV) infection must be receiving anti-retroviral therapy and have an undetectable or unquantifiable viral load at their most recent viral load test within 6 months prior to registration.
-
Patients must not have known active hepatitis B (HBV) or hepatitis C virus (HCV) at date of registration. Patients with previously treated HBV or HCV that have an undetectable viral load within 6 months prior to registration and no residual hepatic impairment are eligible.
-
Patients must not have any known central nervous system lymphoma.
-
Patients must not have a history of or active interstitial pneumonitis or interstitial lung disease.
-
Patients must not have had a diagnosis of inherited or acquired immunodeficiency.
-
Patients must not have any known uncontrolled intercurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, hemodynamically unstable cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
-
Patients must not have a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days prior to registration. Inhaled or topical steroids, and adrenal replacement doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. Steroid use for the control of Hodgkin lymphoma symptoms is allowable, but must be discontinued prior to cycle 1, day 1.
-
Patients with peripheral neuropathy must have < grade 2 at date of registration.
-
Patients must not have active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, immunosuppressive drugs, or corticosteroids with doses higher than prednisone 10 mg or equivalent). Autoimmune diseases include but are not limited to autoimmune hepatitis, inflammatory bowel disease (including ulcerative colitis and Crohn's disease), as well as symptomatic disease (e.g.: rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, autoimmune vasculitis [e.g., Wegener's granulomatosis]); central nervous system (CNS) or motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis, multiple sclerosis or glomerulonephritis). Vitiligo, alopecia, hypothyroidism on stable doses of thyroid replacement therapy, psoriasis not requiring systemic therapy within the past 2 years are permitted.
-
No second prior malignancy is allowed except for adequately treated basal (or squamous cell) skin cancer, any in situ cancer or other cancer for which the patient has been disease free for two years.
-
Females of childbearing potential must not be pregnant or nursing, and have a negative pregnancy test within 28 days prior to registration. Women/men of reproductive potential must have agreed to use an effective contraceptive method while receiving study drug and for women until 6 months after receiving the last dose of study drug or, for men, until 7 months after receiving the last dose of study drug. A woman is considered to be of "reproductive potential" if she has had menses at any time in the preceding 12 consecutive months. In addition to routine contraceptive methods, "effective contraception" also includes heterosexual celibacy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy, bilateral oophorectomy or bilateral tubal ligation. However, if at any point a previously celibate patient chooses to become heterosexually active during the time period for use of contraceptive measures outlined in the protocol, he/she is responsible for beginning contraceptive measures.
-
Patients must have one formalin-fixed paraffin embedded (FFPE) diagnostic tumor block or at least 1 diagnostic, 4-5 micron, hematoxylin and eosin (H&E) slide collected prior to registration and available for submission.
-
Patients must be offered participation in banking for planned translational medicine and future research. With patient consent, any residuals from the mandatory tissue submission will also be banked for future research.
-
Patients who can complete Patient-Reported Outcome instruments in English, Spanish, or French must complete the PROMIS Fatigue, the FACT/GOG-Ntx, and the PROMIS Global prior to registration.
-
Patients who can complete Patient-Reported Outcome instruments in English, Spanish, or French must also agree to complete the PROMIS Fatigue, the FACT/GOG-Ntx, the PROMIS Global, and the PRO-CTCAE (or Ped PRO-CTCAE) at the scheduled on-study assessment timepoints.
-
Patients must be informed of the investigational nature of this study and all patients and/or their parents or legal guardians (for patients < 18 years of age) must sign and give informed consent and assent (where appropriate) in accordance with institutional and federal guidelines. For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board Initiative (CIRB) regulations.
-
Note: As a part of the Oncology Patient Enrollment Network (OPEN) registration process the treating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study has been entered in the system.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Children's Hospital of Alabama | Birmingham | Alabama | United States | 35233 |
| 2 | University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | United States | 35233 |
| 3 | USA Health Strada Patient Care Center | Mobile | Alabama | United States | 36604 |
| 4 | University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | United States | 36688 |
| 5 | Anchorage Associates in Radiation Medicine | Anchorage | Alaska | United States | 98508 |
| 6 | Alaska Breast Care and Surgery LLC | Anchorage | Alaska | United States | 99508 |
| 7 | Alaska Oncology and Hematology LLC | Anchorage | Alaska | United States | 99508 |
| 8 | Alaska Women's Cancer Care | Anchorage | Alaska | United States | 99508 |
| 9 | Anchorage Oncology Centre | Anchorage | Alaska | United States | 99508 |
| 10 | Katmai Oncology Group | Anchorage | Alaska | United States | 99508 |
| 11 | Providence Alaska Medical Center | Anchorage | Alaska | United States | 99508 |
| 12 | Fairbanks Memorial Hospital | Fairbanks | Alaska | United States | 99701 |
| 13 | CTCA at Western Regional Medical Center | Goodyear | Arizona | United States | 85338 |
| 14 | Cancer Center at Saint Joseph's | Phoenix | Arizona | United States | 85004 |
| 15 | Phoenix Childrens Hospital | Phoenix | Arizona | United States | 85016 |
| 16 | University of Arizona Cancer Center-Orange Grove Campus | Tucson | Arizona | United States | 85704 |
| 17 | Banner University Medical Center - Tucson | Tucson | Arizona | United States | 85719 |
| 18 | University of Arizona Cancer Center-North Campus | Tucson | Arizona | United States | 85719 |
| 19 | Mercy Hospital Fort Smith | Fort Smith | Arkansas | United States | 72903 |
| 20 | CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | United States | 71913 |
| 21 | NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | United States | 72401 |
| 22 | Arkansas Children's Hospital | Little Rock | Arkansas | United States | 72202-3591 |
| 23 | University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States | 72205 |
| 24 | Kaiser Permanente-Anaheim | Anaheim | California | United States | 92806 |
| 25 | Kaiser Permanente-Deer Valley Medical Center | Antioch | California | United States | 94531 |
| 26 | PCR Oncology | Arroyo Grande | California | United States | 93420 |
| 27 | Kaiser Permanente-Baldwin Park | Baldwin Park | California | United States | 91706 |
| 28 | Kaiser Permanente-Bellflower | Bellflower | California | United States | 90706 |
| 29 | Tower Cancer Research Foundation | Beverly Hills | California | United States | 90211 |
| 30 | Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | United States | 91505 |
| 31 | City of Hope Comprehensive Cancer Center | Duarte | California | United States | 91010 |
| 32 | Kaiser Permanente Dublin | Dublin | California | United States | 94568 |
| 33 | Kaiser Permanente-Fontana | Fontana | California | United States | 92335 |
| 34 | Kaiser Permanente-Fremont | Fremont | California | United States | 94538 |
| 35 | Kaiser Permanente-Fresno | Fresno | California | United States | 93720 |
| 36 | Kaiser Permanente - Harbor City | Harbor City | California | United States | 90710 |
| 37 | Kaiser Permanente-Irvine | Irvine | California | United States | 92618 |
| 38 | UC San Diego Moores Cancer Center | La Jolla | California | United States | 92093 |
| 39 | Loma Linda University Medical Center | Loma Linda | California | United States | 92354 |
| 40 | Children's Hospital Los Angeles | Los Angeles | California | United States | 90027 |
| 41 | Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | United States | 90027 |
| 42 | Kaiser Permanente West Los Angeles | Los Angeles | California | United States | 90034 |
| 43 | Cedars Sinai Medical Center | Los Angeles | California | United States | 90048 |
| 44 | Valley Children's Hospital | Madera | California | United States | 93636 |
| 45 | Fremont - Rideout Cancer Center | Marysville | California | United States | 95901 |
| 46 | Kaiser Permanente-Modesto | Modesto | California | United States | 95356 |
| 47 | Kaiser Permanente-Oakland | Oakland | California | United States | 94611 |
| 48 | Kaiser Permanente-Ontario | Ontario | California | United States | 91761 |
| 49 | Children's Hospital of Orange County | Orange | California | United States | 92868 |
| 50 | UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | United States | 92868 |
| 51 | Desert Regional Medical Center | Palm Springs | California | United States | 92262 |
| 52 | Stanford Cancer Institute Palo Alto | Palo Alto | California | United States | 94304 |
| 53 | Kaiser Permanente - Panorama City | Panorama City | California | United States | 91402 |
| 54 | Kaiser Permanente-Richmond | Richmond | California | United States | 94801 |
| 55 | Kaiser Permanente-Riverside | Riverside | California | United States | 92505 |
| 56 | Kaiser Permanente Downtown Commons | Sacramento | California | United States | 95814 |
| 57 | Sutter Medical Center Sacramento | Sacramento | California | United States | 95816 |
| 58 | University of California Davis Comprehensive Cancer Center | Sacramento | California | United States | 95817 |
| 59 | Kaiser Permanente-South Sacramento | Sacramento | California | United States | 95823 |
| 60 | Kaiser Permanente-San Diego Zion | San Diego | California | United States | 92120 |
| 61 | Rady Children's Hospital - San Diego | San Diego | California | United States | 92123 |
| 62 | Naval Medical Center -San Diego | San Diego | California | United States | 92134 |
| 63 | Kaiser Permanente-San Francisco | San Francisco | California | United States | 94115 |
| 64 | UCSF Medical Center-Mission Bay | San Francisco | California | United States | 94158 |
| 65 | Kaiser Permanente-Santa Teresa-San Jose | San Jose | California | United States | 95119 |
| 66 | Kaiser Permanente San Leandro | San Leandro | California | United States | 94577 |
| 67 | Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo | California | United States | 93401 |
| 68 | Kaiser Permanente-San Marcos | San Marcos | California | United States | 92078 |
| 69 | Kaiser San Rafael-Gallinas | San Rafael | California | United States | 94903 |
| 70 | Mission Hope Medical Oncology - Santa Maria | Santa Maria | California | United States | 93444 |
| 71 | Kaiser Permanente-Santa Rosa | Santa Rosa | California | United States | 95403 |
| 72 | Kaiser Permanente-South San Francisco | South San Francisco | California | United States | 94080 |
| 73 | Kaiser Permanente-Stockton | Stockton | California | United States | 95210 |
| 74 | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | United States | 90502 |
| 75 | Kaiser Permanente Medical Center-Vacaville | Vacaville | California | United States | 95688 |
| 76 | Kaiser Permanente-Vallejo | Vallejo | California | United States | 94589 |
| 77 | Kaiser Permanente-Walnut Creek | Walnut Creek | California | United States | 94596 |
| 78 | Presbyterian Intercommunity Hospital | Whittier | California | United States | 90602 |
| 79 | Kaiser Permanente-Woodland Hills | Woodland Hills | California | United States | 91367 |
| 80 | Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | United States | 80012 |
| 81 | The Medical Center of Aurora | Aurora | Colorado | United States | 80012 |
| 82 | Children's Hospital Colorado | Aurora | Colorado | United States | 80045 |
| 83 | University of Colorado Hospital | Aurora | Colorado | United States | 80045 |
| 84 | Boulder Community Hospital | Boulder | Colorado | United States | 80301 |
| 85 | Boulder Community Foothills Hospital | Boulder | Colorado | United States | 80303 |
| 86 | Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | United States | 80304 |
| 87 | Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | United States | 80907 |
| 88 | Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | United States | 80907 |
| 89 | Kaiser Permanente-Franklin | Denver | Colorado | United States | 80205 |
| 90 | Porter Adventist Hospital | Denver | Colorado | United States | 80210 |
| 91 | Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | United States | 80218 |
| 92 | Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center | Denver | Colorado | United States | 80218 |
| 93 | SCL Health Saint Joseph Hospital | Denver | Colorado | United States | 80218 |
| 94 | Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | United States | 80113 |
| 95 | Swedish Medical Center | Englewood | Colorado | United States | 80113 |
| 96 | Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | United States | 81501 |
| 97 | North Colorado Medical Center | Greeley | Colorado | United States | 80631 |
| 98 | Kaiser Permanente-Rock Creek | Lafayette | Colorado | United States | 80026 |
| 99 | Saint Anthony Hospital | Lakewood | Colorado | United States | 80228 |
| 100 | Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | United States | 80120 |
| 101 | Littleton Adventist Hospital | Littleton | Colorado | United States | 80122 |
| 102 | Kaiser Permanente-Lone Tree | Lone Tree | Colorado | United States | 80124 |
| 103 | Sky Ridge Medical Center | Lone Tree | Colorado | United States | 80124 |
| 104 | Longmont United Hospital | Longmont | Colorado | United States | 80501 |
| 105 | McKee Medical Center | Loveland | Colorado | United States | 80539 |
| 106 | Parker Adventist Hospital | Parker | Colorado | United States | 80138 |
| 107 | Saint Mary Corwin Medical Center | Pueblo | Colorado | United States | 81004 |
| 108 | Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | United States | 80260 |
| 109 | SCL Health Lutheran Medical Center | Wheat Ridge | Colorado | United States | 80033 |
| 110 | Smilow Cancer Hospital-Derby Care Center | Derby | Connecticut | United States | 06418 |
| 111 | Connecticut Children's Medical Center | Hartford | Connecticut | United States | 06106 |
| 112 | Smilow Cancer Center/Yale-New Haven Hospital | New Haven | Connecticut | United States | 06510 |
| 113 | Yale University | New Haven | Connecticut | United States | 06520 |
| 114 | Smilow Cancer Hospital-Orange Care Center | Orange | Connecticut | United States | 06477 |
| 115 | Smilow Cancer Hospital Care Center-Trumbull | Trumbull | Connecticut | United States | 06611 |
| 116 | Smilow Cancer Hospital Care Center - Waterford | Waterford | Connecticut | United States | 06385 |
| 117 | Beebe South Coastal Health Campus | Frankford | Delaware | United States | 19945 |
| 118 | Beebe Medical Center | Lewes | Delaware | United States | 19958 |
| 119 | Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | United States | 19713 |
| 120 | Helen F Graham Cancer Center | Newark | Delaware | United States | 19713 |
| 121 | Medical Oncology Hematology Consultants PA | Newark | Delaware | United States | 19713 |
| 122 | Christiana Care Health System-Christiana Hospital | Newark | Delaware | United States | 19718 |
| 123 | Beebe Health Campus | Rehoboth Beach | Delaware | United States | 19971 |
| 124 | TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware | United States | 19973 |
| 125 | Alfred I duPont Hospital for Children | Wilmington | Delaware | United States | 19803 |
| 126 | MedStar Georgetown University Hospital | Washington | District of Columbia | United States | 20007 |
| 127 | Children's National Medical Center | Washington | District of Columbia | United States | 20010 |
| 128 | UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | United States | 33146 |
| 129 | Broward Health Medical Center | Fort Lauderdale | Florida | United States | 33316 |
| 130 | Regional Cancer Center-Lee Memorial Health System | Fort Myers | Florida | United States | 33905 |
| 131 | Golisano Children's Hospital of Southwest Florida | Fort Myers | Florida | United States | 33908 |
| 132 | University of Florida Health Science Center - Gainesville | Gainesville | Florida | United States | 32610 |
| 133 | Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | United States | 33021 |
| 134 | UM Sylvester Comprehensive Cancer Center at Hollywood | Hollywood | Florida | United States | 33021 |
| 135 | Nemours Children's Clinic-Jacksonville | Jacksonville | Florida | United States | 32207 |
| 136 | Palms West Radiation Therapy | Loxahatchee Groves | Florida | United States | 33470 |
| 137 | Mount Sinai Medical Center | Miami Beach | Florida | United States | 33140 |
| 138 | University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | United States | 33136 |
| 139 | Nicklaus Children's Hospital | Miami | Florida | United States | 33155 |
| 140 | Miami Cancer Institute | Miami | Florida | United States | 33176 |
| 141 | Orlando Health Cancer Institute | Orlando | Florida | United States | 32806 |
| 142 | Nemours Children's Hospital | Orlando | Florida | United States | 32827 |
| 143 | Sacred Heart Hospital | Pensacola | Florida | United States | 32504 |
| 144 | Johns Hopkins All Children's Hospital | Saint Petersburg | Florida | United States | 33701 |
| 145 | Moffitt Cancer Center-International Plaza | Tampa | Florida | United States | 33607 |
| 146 | Saint Joseph's Hospital/Children's Hospital-Tampa | Tampa | Florida | United States | 33607 |
| 147 | Moffitt Cancer Center - McKinley Campus | Tampa | Florida | United States | 33612 |
| 148 | Moffitt Cancer Center | Tampa | Florida | United States | 33612 |
| 149 | Saint Mary's Hospital | West Palm Beach | Florida | United States | 33407 |
| 150 | Children's Healthcare of Atlanta - Egleston | Atlanta | Georgia | United States | 30322 |
| 151 | Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | United States | 30322 |
| 152 | Emory Saint Joseph's Hospital | Atlanta | Georgia | United States | 30342 |
| 153 | Augusta University Medical Center | Augusta | Georgia | United States | 30912 |
| 154 | Memorial Health University Medical Center | Savannah | Georgia | United States | 31404 |
| 155 | Hawaii Cancer Care - Savio | 'Aiea | Hawaii | United States | 96701 |
| 156 | Pali Momi Medical Center | 'Aiea | Hawaii | United States | 96701 |
| 157 | Queen's Cancer Center - Pearlridge | 'Aiea | Hawaii | United States | 96701 |
| 158 | The Cancer Center of Hawaii-Pali Momi | 'Aiea | Hawaii | United States | 96701 |
| 159 | Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu | Hawaii | United States | 96813 |
| 160 | Queen's Cancer Cenrer - POB I | Honolulu | Hawaii | United States | 96813 |
| 161 | Queen's Medical Center | Honolulu | Hawaii | United States | 96813 |
| 162 | Straub Clinic and Hospital | Honolulu | Hawaii | United States | 96813 |
| 163 | University of Hawaii Cancer Center | Honolulu | Hawaii | United States | 96813 |
| 164 | Hawaii Cancer Care Inc-Liliha | Honolulu | Hawaii | United States | 96817 |
| 165 | Kuakini Medical Center | Honolulu | Hawaii | United States | 96817 |
| 166 | Queen's Cancer Center - Kuakini | Honolulu | Hawaii | United States | 96817 |
| 167 | The Cancer Center of Hawaii-Liliha | Honolulu | Hawaii | United States | 96817 |
| 168 | Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | United States | 96826 |
| 169 | Wilcox Memorial Hospital and Kauai Medical Clinic | Lihue | Hawaii | United States | 96766 |
| 170 | Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | United States | 83706 |
| 171 | Saint Luke's Cancer Institute - Boise | Boise | Idaho | United States | 83712 |
| 172 | Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | United States | 83605 |
| 173 | Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | United States | 83814 |
| 174 | Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | United States | 83619 |
| 175 | Idaho Urologic Institute-Meridian | Meridian | Idaho | United States | 83642 |
| 176 | Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | United States | 83642 |
| 177 | Saint Alphonsus Medical Center-Nampa | Nampa | Idaho | United States | 83686 |
| 178 | Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | United States | 83686 |
| 179 | Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | United States | 83854 |
| 180 | Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | United States | 83301 |
| 181 | Rush - Copley Medical Center | Aurora | Illinois | United States | 60504 |
| 182 | Illinois CancerCare-Bloomington | Bloomington | Illinois | United States | 61704 |
| 183 | Illinois CancerCare-Canton | Canton | Illinois | United States | 61520 |
| 184 | Memorial Hospital of Carbondale | Carbondale | Illinois | United States | 62902 |
| 185 | SIH Cancer Institute | Carterville | Illinois | United States | 62918 |
| 186 | Illinois CancerCare-Carthage | Carthage | Illinois | United States | 62321 |
| 187 | Centralia Oncology Clinic | Centralia | Illinois | United States | 62801 |
| 188 | Northwestern University | Chicago | Illinois | United States | 60611 |
| 189 | Rush University Medical Center | Chicago | Illinois | United States | 60612 |
| 190 | University of Illinois | Chicago | Illinois | United States | 60612 |
| 191 | University of Chicago Comprehensive Cancer Center | Chicago | Illinois | United States | 60637 |
| 192 | Carle on Vermilion | Danville | Illinois | United States | 61832 |
| 193 | Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | United States | 62526 |
| 194 | Decatur Memorial Hospital | Decatur | Illinois | United States | 62526 |
| 195 | Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | United States | 60115 |
| 196 | Illinois CancerCare-Dixon | Dixon | Illinois | United States | 61021 |
| 197 | Carle Physician Group-Effingham | Effingham | Illinois | United States | 62401 |
| 198 | Crossroads Cancer Center | Effingham | Illinois | United States | 62401 |
| 199 | Illinois CancerCare-Eureka | Eureka | Illinois | United States | 61530 |
| 200 | NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | United States | 60201 |
| 201 | Illinois CancerCare-Galesburg | Galesburg | Illinois | United States | 61401 |
| 202 | Western Illinois Cancer Treatment Center | Galesburg | Illinois | United States | 61401 |
| 203 | Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | United States | 60134 |
| 204 | NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | United States | 60026 |
| 205 | Ingalls Memorial Hospital | Harvey | Illinois | United States | 60426 |
| 206 | NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | United States | 60035 |
| 207 | AMITA Health Cancer Institute and Outpatient Center | Hinsdale | Illinois | United States | 60521 |
| 208 | Duly Health and Care Joliet | Joliet | Illinois | United States | 60435 |
| 209 | Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | United States | 61443 |
| 210 | Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | United States | 60045 |
| 211 | Illinois CancerCare-Macomb | Macomb | Illinois | United States | 61455 |
| 212 | Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | United States | 61938 |
| 213 | Loyola University Medical Center | Maywood | Illinois | United States | 60153 |
| 214 | Good Samaritan Regional Health Center | Mount Vernon | Illinois | United States | 62864 |
| 215 | UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | United States | 60451 |
| 216 | Cancer Care Center of O'Fallon | O'Fallon | Illinois | United States | 62269 |
| 217 | Advocate Children's Hospital-Oak Lawn | Oak Lawn | Illinois | United States | 60453 |
| 218 | University of Chicago Medicine-Orland Park | Orland Park | Illinois | United States | 60462 |
| 219 | Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | United States | 61350 |
| 220 | Advocate Children's Hospital-Park Ridge | Park Ridge | Illinois | United States | 60068 |
| 221 | Illinois CancerCare-Pekin | Pekin | Illinois | United States | 61554 |
| 222 | OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | United States | 61554 |
| 223 | Illinois CancerCare-Peoria | Peoria | Illinois | United States | 61615 |
| 224 | OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | United States | 61615 |
| 225 | Methodist Medical Center of Illinois | Peoria | Illinois | United States | 61636 |
| 226 | OSF Saint Francis Medical Center | Peoria | Illinois | United States | 61637 |
| 227 | Illinois CancerCare-Peru | Peru | Illinois | United States | 61354 |
| 228 | Valley Radiation Oncology | Peru | Illinois | United States | 61354 |
| 229 | Illinois CancerCare-Princeton | Princeton | Illinois | United States | 61356 |
| 230 | Southern Illinois University School of Medicine | Springfield | Illinois | United States | 62702 |
| 231 | Springfield Clinic | Springfield | Illinois | United States | 62702 |
| 232 | Memorial Medical Center | Springfield | Illinois | United States | 62781 |
| 233 | Southwest Illinois Health Services LLP | Swansea | Illinois | United States | 62226 |
| 234 | Carle Cancer Center | Urbana | Illinois | United States | 61801 |
| 235 | The Carle Foundation Hospital | Urbana | Illinois | United States | 61801 |
| 236 | Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | United States | 60555 |
| 237 | Illinois CancerCare - Washington | Washington | Illinois | United States | 61571 |
| 238 | Parkview Regional Medical Center | Fort Wayne | Indiana | United States | 46845 |
| 239 | Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | United States | 46202 |
| 240 | Riley Hospital for Children | Indianapolis | Indiana | United States | 46202 |
| 241 | Saint Vincent Hospital and Health Care Center | Indianapolis | Indiana | United States | 46260 |
| 242 | McFarland Clinic PC - Ames | Ames | Iowa | United States | 50010 |
| 243 | Saint Anthony Regional Hospital | Carroll | Iowa | United States | 51401 |
| 244 | Mercy Hospital | Cedar Rapids | Iowa | United States | 52403 |
| 245 | Oncology Associates at Mercy Medical Center | Cedar Rapids | Iowa | United States | 52403 |
| 246 | Medical Oncology and Hematology Associates-West Des Moines | Clive | Iowa | United States | 50325 |
| 247 | Mercy Cancer Center-West Lakes | Clive | Iowa | United States | 50325 |
| 248 | Greater Regional Medical Center | Creston | Iowa | United States | 50801 |
| 249 | Blank Children's Hospital | Des Moines | Iowa | United States | 50309 |
| 250 | Iowa Methodist Medical Center | Des Moines | Iowa | United States | 50309 |
| 251 | Medical Oncology and Hematology Associates-Des Moines | Des Moines | Iowa | United States | 50309 |
| 252 | Broadlawns Medical Center | Des Moines | Iowa | United States | 50314 |
| 253 | Medical Oncology and Hematology Associates-Laurel | Des Moines | Iowa | United States | 50314 |
| 254 | Mercy Medical Center - Des Moines | Des Moines | Iowa | United States | 50314 |
| 255 | Iowa Lutheran Hospital | Des Moines | Iowa | United States | 50316 |
| 256 | University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | United States | 52242 |
| 257 | Methodist West Hospital | West Des Moines | Iowa | United States | 50266-7700 |
| 258 | Mercy Medical Center-West Lakes | West Des Moines | Iowa | United States | 50266 |
| 259 | Central Care Cancer Center - Garden City | Garden City | Kansas | United States | 67846 |
| 260 | Central Care Cancer Center - Great Bend | Great Bend | Kansas | United States | 67530 |
| 261 | University of Kansas Cancer Center-West | Kansas City | Kansas | United States | 66112 |
| 262 | University of Kansas Cancer Center | Kansas City | Kansas | United States | 66160 |
| 263 | University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | United States | 66210 |
| 264 | University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | United States | 66205 |
| 265 | Saint Joseph Radiation Oncology Resource Center | Lexington | Kentucky | United States | 40504 |
| 266 | Saint Joseph Hospital East | Lexington | Kentucky | United States | 40509 |
| 267 | University of Kentucky/Markey Cancer Center | Lexington | Kentucky | United States | 40536 |
| 268 | Jewish Hospital | Louisville | Kentucky | United States | 40202 |
| 269 | Norton Children's Hospital | Louisville | Kentucky | United States | 40202 |
| 270 | Norton Suburban Hospital and Medical Campus | Louisville | Kentucky | United States | 40207 |
| 271 | UofL Health Medical Center Northeast | Louisville | Kentucky | United States | 40245 |
| 272 | Ochsner Medical Center Kenner | Kenner | Louisiana | United States | 70065 |
| 273 | Children's Hospital New Orleans | New Orleans | Louisiana | United States | 70118 |
| 274 | Ochsner Medical Center Jefferson | New Orleans | Louisiana | United States | 70121 |
| 275 | LSU Health Sciences Center at Shreveport | Shreveport | Louisiana | United States | 71103 |
| 276 | Harold Alfond Center for Cancer Care | Augusta | Maine | United States | 04330 |
| 277 | Eastern Maine Medical Center | Bangor | Maine | United States | 04401 |
| 278 | MaineHealth Coastal Cancer Treatment Center | Bath | Maine | United States | 04530 |
| 279 | Waldo County General Hospital | Belfast | Maine | United States | 04915 |
| 280 | MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | United States | 04005 |
| 281 | Maine Medical Center-Bramhall Campus | Portland | Maine | United States | 04102 |
| 282 | Penobscot Bay Medical Center | Rockport | Maine | United States | 04856 |
| 283 | MaineHealth Cancer Care Center of York County | Sanford | Maine | United States | 04073 |
| 284 | MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford | Maine | United States | 04073 |
| 285 | Maine Medical Center- Scarborough Campus | Scarborough | Maine | United States | 04074 |
| 286 | Maine Medical Partners - South Portland | South Portland | Maine | United States | 04106 |
| 287 | University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | United States | 21201 |
| 288 | Sinai Hospital of Baltimore | Baltimore | Maryland | United States | 21215 |
| 289 | Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | United States | 21287 |
| 290 | UM Upper Chesapeake Medical Center | Bel Air | Maryland | United States | 21014 |
| 291 | Walter Reed National Military Medical Center | Bethesda | Maryland | United States | 20889-5600 |
| 292 | Tufts Children's Hospital | Boston | Massachusetts | United States | 02111 |
| 293 | Tufts Medical Center | Boston | Massachusetts | United States | 02111 |
| 294 | Massachusetts General Hospital Cancer Center | Boston | Massachusetts | United States | 02114 |
| 295 | Brigham and Women's Hospital | Boston | Massachusetts | United States | 02115 |
| 296 | Boston Medical Center | Boston | Massachusetts | United States | 02118 |
| 297 | Dana-Farber Cancer Institute | Boston | Massachusetts | United States | 02215 |
| 298 | Baystate Medical Center | Springfield | Massachusetts | United States | 01199 |
| 299 | Saint Joseph Mercy Hospital | Ann Arbor | Michigan | United States | 48106 |
| 300 | C S Mott Children's Hospital | Ann Arbor | Michigan | United States | 48109 |
| 301 | Bronson Battle Creek | Battle Creek | Michigan | United States | 49017 |
| 302 | Saint Joseph Mercy Brighton | Brighton | Michigan | United States | 48114 |
| 303 | Trinity Health IHA Medical Group Hematology Oncology - Brighton | Brighton | Michigan | United States | 48114 |
| 304 | Henry Ford Cancer Institute-Downriver | Brownstown | Michigan | United States | 48183 |
| 305 | Saint Joseph Mercy Canton | Canton | Michigan | United States | 48188 |
| 306 | Trinity Health IHA Medical Group Hematology Oncology - Canton | Canton | Michigan | United States | 48188 |
| 307 | Saint Joseph Mercy Chelsea | Chelsea | Michigan | United States | 48118 |
| 308 | Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital | Chelsea | Michigan | United States | 48118 |
| 309 | Henry Ford Macomb Hospital-Clinton Township | Clinton Township | Michigan | United States | 48038 |
| 310 | Beaumont Hospital - Dearborn | Dearborn | Michigan | United States | 48124 |
| 311 | Henry Ford Medical Center-Fairlane | Dearborn | Michigan | United States | 48126 |
| 312 | Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | United States | 48201 |
| 313 | Henry Ford Hospital | Detroit | Michigan | United States | 48202 |
| 314 | Ascension Saint John Hospital | Detroit | Michigan | United States | 48236 |
| 315 | Weisberg Cancer Treatment Center | Farmington Hills | Michigan | United States | 48334 |
| 316 | Helen DeVos Children's Hospital at Spectrum Health | Grand Rapids | Michigan | United States | 49503 |
| 317 | Mercy Health Saint Mary's | Grand Rapids | Michigan | United States | 49503 |
| 318 | Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | United States | 49503 |
| 319 | Allegiance Health | Jackson | Michigan | United States | 49201 |
| 320 | Bronson Methodist Hospital | Kalamazoo | Michigan | United States | 49007 |
| 321 | West Michigan Cancer Center | Kalamazoo | Michigan | United States | 49007 |
| 322 | Borgess Medical Center | Kalamazoo | Michigan | United States | 49048 |
| 323 | Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | United States | 48154 |
| 324 | Mercy Health Mercy Campus | Muskegon | Michigan | United States | 49444 |
| 325 | Lakeland Hospital Niles | Niles | Michigan | United States | 49120 |
| 326 | Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | United States | 49444 |
| 327 | Ascension Providence Hospitals - Novi | Novi | Michigan | United States | 48374 |
| 328 | Henry Ford Medical Center-Columbus | Novi | Michigan | United States | 48377 |
| 329 | Spectrum Health Reed City Hospital | Reed City | Michigan | United States | 49677 |
| 330 | Beaumont Children's Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 331 | William Beaumont Hospital-Royal Oak | Royal Oak | Michigan | United States | 48073 |
| 332 | Lakeland Medical Center Saint Joseph | Saint Joseph | Michigan | United States | 49085 |
| 333 | Marie Yeager Cancer Center | Saint Joseph | Michigan | United States | 49085 |
| 334 | Henry Ford Macomb Health Center - Shelby Township | Shelby | Michigan | United States | 48315 |
| 335 | Ascension Providence Hospitals - Southfield | Southfield | Michigan | United States | 48075 |
| 336 | Munson Medical Center | Traverse City | Michigan | United States | 49684 |
| 337 | William Beaumont Hospital - Troy | Troy | Michigan | United States | 48085 |
| 338 | Henry Ford West Bloomfield Hospital | West Bloomfield | Michigan | United States | 48322 |
| 339 | Metro Health Hospital | Wyoming | Michigan | United States | 49519 |
| 340 | Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus | Ypsilanti | Michigan | United States | 48197 |
| 341 | Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | United States | 56601 |
| 342 | Essentia Health Saint Joseph's Medical Center | Brainerd | Minnesota | United States | 56401 |
| 343 | Fairview Ridges Hospital | Burnsville | Minnesota | United States | 55337 |
| 344 | Minnesota Oncology - Burnsville | Burnsville | Minnesota | United States | 55337 |
| 345 | Mercy Hospital | Coon Rapids | Minnesota | United States | 55433 |
| 346 | Essentia Health - Deer River Clinic | Deer River | Minnesota | United States | 56636 |
| 347 | Essentia Health Saint Mary's - Detroit Lakes Clinic | Detroit Lakes | Minnesota | United States | 56501 |
| 348 | Essentia Health Cancer Center | Duluth | Minnesota | United States | 55805 |
| 349 | Essentia Health Saint Mary's Medical Center | Duluth | Minnesota | United States | 55805 |
| 350 | Miller-Dwan Hospital | Duluth | Minnesota | United States | 55805 |
| 351 | Fairview Southdale Hospital | Edina | Minnesota | United States | 55435 |
| 352 | Lake Region Healthcare Corporation-Cancer Care | Fergus Falls | Minnesota | United States | 56537 |
| 353 | Essentia Health - Fosston | Fosston | Minnesota | United States | 56542 |
| 354 | Unity Hospital | Fridley | Minnesota | United States | 55432 |
| 355 | Essentia Health Hibbing Clinic | Hibbing | Minnesota | United States | 55746 |
| 356 | Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | United States | 55369 |
| 357 | Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | United States | 55109 |
| 358 | Saint John's Hospital - Healtheast | Maplewood | Minnesota | United States | 55109 |
| 359 | Children's Hospitals and Clinics of Minnesota - Minneapolis | Minneapolis | Minnesota | United States | 55404 |
| 360 | Abbott-Northwestern Hospital | Minneapolis | Minnesota | United States | 55407 |
| 361 | Hennepin County Medical Center | Minneapolis | Minnesota | United States | 55415 |
| 362 | Health Partners Inc | Minneapolis | Minnesota | United States | 55454 |
| 363 | Monticello Cancer Center | Monticello | Minnesota | United States | 55362 |
| 364 | Essentia Health - Park Rapids | Park Rapids | Minnesota | United States | 56470 |
| 365 | North Memorial Medical Health Center | Robbinsdale | Minnesota | United States | 55422 |
| 366 | Mayo Clinic in Rochester | Rochester | Minnesota | United States | 55905 |
| 367 | Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | United States | 55416 |
| 368 | Regions Hospital | Saint Paul | Minnesota | United States | 55101 |
| 369 | United Hospital | Saint Paul | Minnesota | United States | 55102 |
| 370 | Essentia Health Sandstone | Sandstone | Minnesota | United States | 55072 |
| 371 | Saint Francis Regional Medical Center | Shakopee | Minnesota | United States | 55379 |
| 372 | Lakeview Hospital | Stillwater | Minnesota | United States | 55082 |
| 373 | Essentia Health Virginia Clinic | Virginia | Minnesota | United States | 55792 |
| 374 | Ridgeview Medical Center | Waconia | Minnesota | United States | 55387 |
| 375 | Rice Memorial Hospital | Willmar | Minnesota | United States | 56201 |
| 376 | Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | United States | 55125 |
| 377 | Baptist Memorial Hospital and Cancer Center-Golden Triangle | Columbus | Mississippi | United States | 39705 |
| 378 | Baptist Cancer Center-Grenada | Grenada | Mississippi | United States | 38901 |
| 379 | University of Mississippi Medical Center | Jackson | Mississippi | United States | 39216 |
| 380 | Baptist Memorial Hospital and Cancer Center-Union County | New Albany | Mississippi | United States | 38652 |
| 381 | Baptist Memorial Hospital and Cancer Center-Oxford | Oxford | Mississippi | United States | 38655 |
| 382 | Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven | Mississippi | United States | 38671 |
| 383 | Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | United States | 63011 |
| 384 | Central Care Cancer Center - Bolivar | Bolivar | Missouri | United States | 65613 |
| 385 | Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | United States | 63628 |
| 386 | Saint Francis Medical Center | Cape Girardeau | Missouri | United States | 63703 |
| 387 | Southeast Cancer Center | Cape Girardeau | Missouri | United States | 63703 |
| 388 | Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | United States | 63141 |
| 389 | Parkland Health Center - Farmington | Farmington | Missouri | United States | 63640 |
| 390 | Capital Region Southwest Campus | Jefferson City | Missouri | United States | 65109 |
| 391 | Freeman Health System | Joplin | Missouri | United States | 64804 |
| 392 | Mercy Hospital Joplin | Joplin | Missouri | United States | 64804 |
| 393 | Children's Mercy Hospitals and Clinics | Kansas City | Missouri | United States | 64108 |
| 394 | University of Kansas Cancer Center - North | Kansas City | Missouri | United States | 64154 |
| 395 | University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | United States | 64064 |
| 396 | University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City | Missouri | United States | 64116 |
| 397 | Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | United States | 65401 |
| 398 | Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | United States | 65401 |
| 399 | Heartland Regional Medical Center | Saint Joseph | Missouri | United States | 64506 |
| 400 | Cardinal Glennon Children's Medical Center | Saint Louis | Missouri | United States | 63104 |
| 401 | Washington University School of Medicine | Saint Louis | Missouri | United States | 63110 |
| 402 | Mercy Hospital South | Saint Louis | Missouri | United States | 63128 |
| 403 | Siteman Cancer Center-South County | Saint Louis | Missouri | United States | 63129 |
| 404 | Missouri Baptist Medical Center | Saint Louis | Missouri | United States | 63131 |
| 405 | Siteman Cancer Center at Christian Hospital | Saint Louis | Missouri | United States | 63136 |
| 406 | Mercy Hospital Saint Louis | Saint Louis | Missouri | United States | 63141 |
| 407 | Siteman Cancer Center at Saint Peters Hospital | Saint Peters | Missouri | United States | 63376 |
| 408 | Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | United States | 63670 |
| 409 | Mercy Hospital Springfield | Springfield | Missouri | United States | 65804 |
| 410 | CoxHealth South Hospital | Springfield | Missouri | United States | 65807 |
| 411 | Missouri Baptist Sullivan Hospital | Sullivan | Missouri | United States | 63080 |
| 412 | Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | United States | 63127 |
| 413 | Billings Clinic Cancer Center | Billings | Montana | United States | 59101 |
| 414 | Saint Vincent Healthcare | Billings | Montana | United States | 59101 |
| 415 | Bozeman Deaconess Hospital | Bozeman | Montana | United States | 59715 |
| 416 | Saint James Community Hospital and Cancer Treatment Center | Butte | Montana | United States | 59701 |
| 417 | Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | United States | 59405 |
| 418 | Great Falls Clinic | Great Falls | Montana | United States | 59405 |
| 419 | Kalispell Regional Medical Center | Kalispell | Montana | United States | 59901 |
| 420 | Community Medical Hospital | Missoula | Montana | United States | 59804 |
| 421 | Nebraska Medicine-Bellevue | Bellevue | Nebraska | United States | 68123 |
| 422 | CHI Health Saint Francis | Grand Island | Nebraska | United States | 68803 |
| 423 | CHI Health Good Samaritan | Kearney | Nebraska | United States | 68847 |
| 424 | Nebraska Medicine-Village Pointe | Omaha | Nebraska | United States | 68118 |
| 425 | Alegent Health Immanuel Medical Center | Omaha | Nebraska | United States | 68122 |
| 426 | Alegent Health Bergan Mercy Medical Center | Omaha | Nebraska | United States | 68124 |
| 427 | Alegent Health Lakeside Hospital | Omaha | Nebraska | United States | 68130 |
| 428 | Creighton University Medical Center | Omaha | Nebraska | United States | 68131 |
| 429 | University of Nebraska Medical Center | Omaha | Nebraska | United States | 68198 |
| 430 | Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | United States | 89052 |
| 431 | OptumCare Cancer Care at Seven Hills | Henderson | Nevada | United States | 89052 |
| 432 | OptumCare Cancer Care at Charleston | Las Vegas | Nevada | United States | 89102 |
| 433 | Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | United States | 89106 |
| 434 | GenesisCare USA - Las Vegas | Las Vegas | Nevada | United States | 89109 |
| 435 | Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | United States | 89119 |
| 436 | Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | United States | 89128 |
| 437 | OptumCare Cancer Care at MountainView | Las Vegas | Nevada | United States | 89128 |
| 438 | Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | United States | 89135 |
| 439 | Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | United States | 89144 |
| 440 | Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | United States | 89144 |
| 441 | Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | United States | 89148 |
| 442 | OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | United States | 89148 |
| 443 | Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | United States | 89169 |
| 444 | Renown Regional Medical Center | Reno | Nevada | United States | 89502 |
| 445 | Saint Mary's Regional Medical Center | Reno | Nevada | United States | 89503 |
| 446 | Radiation Oncology Associates | Reno | Nevada | United States | 89509 |
| 447 | Cancer Care Specialists - Reno | Reno | Nevada | United States | 89511 |
| 448 | Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | United States | 03756 |
| 449 | Norris Cotton Cancer Center-Nashua | Nashua | New Hampshire | United States | 03063 |
| 450 | Cooper Hospital University Medical Center | Camden | New Jersey | United States | 08103 |
| 451 | Hackensack University Medical Center | Hackensack | New Jersey | United States | 07601 |
| 452 | Saint Barnabas Medical Center | Livingston | New Jersey | United States | 07039 |
| 453 | Morristown Medical Center | Morristown | New Jersey | United States | 07960 |
| 454 | Saint Peter's University Hospital | New Brunswick | New Jersey | United States | 08901 |
| 455 | Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital | New Brunswick | New Jersey | United States | 08903 |
| 456 | Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | United States | 08903 |
| 457 | Rutgers New Jersey Medical School | Newark | New Jersey | United States | 07101 |
| 458 | Newark Beth Israel Medical Center | Newark | New Jersey | United States | 07112 |
| 459 | The Valley Hospital-Luckow Pavilion | Paramus | New Jersey | United States | 07652 |
| 460 | Saint Joseph's Regional Medical Center | Paterson | New Jersey | United States | 07503 |
| 461 | Valley Hospital | Ridgewood | New Jersey | United States | 07450 |
| 462 | Overlook Hospital | Summit | New Jersey | United States | 07902 |
| 463 | MD Anderson Cancer Center at Cooper-Voorhees | Voorhees | New Jersey | United States | 08043 |
| 464 | Valley Health System-Hematology/Oncology | Westwood | New Jersey | United States | 07675 |
| 465 | University of New Mexico Cancer Center | Albuquerque | New Mexico | United States | 87102 |
| 466 | Presbyterian Hospital | Albuquerque | New Mexico | United States | 87106 |
| 467 | Albany Medical Center | Albany | New York | United States | 12208 |
| 468 | Montefiore Medical Center - Moses Campus | Bronx | New York | United States | 10467 |
| 469 | New York-Presbyterian/Brooklyn Methodist Hospital | Brooklyn | New York | United States | 11215 |
| 470 | Roswell Park Cancer Institute | Buffalo | New York | United States | 14263 |
| 471 | Hematology Oncology Associates of Central New York-East Syracuse | East Syracuse | New York | United States | 13057 |
| 472 | Glens Falls Hospital | Glens Falls | New York | United States | 12801 |
| 473 | NYU Winthrop Hospital | Mineola | New York | United States | 11501 |
| 474 | NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | United States | 10032 |
| 475 | Memorial Sloan Kettering Cancer Center | New York | New York | United States | 10065 |
| 476 | NYP/Weill Cornell Medical Center | New York | New York | United States | 10065 |
| 477 | University of Rochester | Rochester | New York | United States | 14642 |
| 478 | Stony Brook University Medical Center | Stony Brook | New York | United States | 11794 |
| 479 | State University of New York Upstate Medical University | Syracuse | New York | United States | 13210 |
| 480 | Hematology Oncology Associates of Central New York-Onondaga Hill | Syracuse | New York | United States | 13215 |
| 481 | Atrium Health Stanly/LCI-Albemarle | Albemarle | North Carolina | United States | 28002 |
| 482 | UNC Lineberger Comprehensive Cancer Center | Chapel Hill | North Carolina | United States | 27599 |
| 483 | Carolinas Medical Center/Levine Cancer Institute | Charlotte | North Carolina | United States | 28203 |
| 484 | Novant Health Presbyterian Medical Center | Charlotte | North Carolina | United States | 28204 |
| 485 | Atrium Health Pineville/LCI-Pineville | Charlotte | North Carolina | United States | 28210 |
| 486 | Atrium Health University City/LCI-University | Charlotte | North Carolina | United States | 28262 |
| 487 | Wake Forest University at Clemmons | Clemmons | North Carolina | United States | 27012 |
| 488 | Atrium Health Cabarrus/LCI-Concord | Concord | North Carolina | United States | 28025 |
| 489 | Duke University Medical Center | Durham | North Carolina | United States | 27710 |
| 490 | East Carolina University | Greenville | North Carolina | United States | 27834 |
| 491 | Vidant Oncology-Kenansville | Kenansville | North Carolina | United States | 28349 |
| 492 | Novant Health Cancer Institute - Kernersville | Kernersville | North Carolina | United States | 27284 |
| 493 | Vidant Oncology-Kinston | Kinston | North Carolina | United States | 28501 |
| 494 | Atrium Health Lincoln/LCI-Lincolnton | Lincolnton | North Carolina | United States | 28092 |
| 495 | Novant Health Cancer Institute - Mount Airy | Mount Airy | North Carolina | United States | 27030 |
| 496 | FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst | North Carolina | United States | 28374 |
| 497 | Vidant Oncology-Richlands | Richlands | North Carolina | United States | 28574 |
| 498 | Novant Health Cancer Institute - Statesville | Statesville | North Carolina | United States | 28625 |
| 499 | Novant Health Cancer Institute - Thomasville | Thomasville | North Carolina | United States | 27360 |
| 500 | Novant Health Cancer Institute - Wilkesboro | Wilkesboro | North Carolina | United States | 28659 |
| 501 | Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | United States | 27103 |
| 502 | Wake Forest University Health Sciences | Winston-Salem | North Carolina | United States | 27157 |
| 503 | Sanford Bismarck Medical Center | Bismarck | North Dakota | United States | 58501 |
| 504 | Essentia Health Cancer Center-South University Clinic | Fargo | North Dakota | United States | 58103 |
| 505 | Sanford Broadway Medical Center | Fargo | North Dakota | United States | 58122 |
| 506 | Sanford Roger Maris Cancer Center | Fargo | North Dakota | United States | 58122 |
| 507 | Essentia Health - Jamestown Clinic | Jamestown | North Dakota | United States | 58401 |
| 508 | Children's Hospital Medical Center of Akron | Akron | Ohio | United States | 44308 |
| 509 | Cleveland Clinic Mercy Hospital | Canton | Ohio | United States | 44708 |
| 510 | Adena Regional Medical Center | Chillicothe | Ohio | United States | 45601 |
| 511 | University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | United States | 45219 |
| 512 | Good Samaritan Hospital - Cincinnati | Cincinnati | Ohio | United States | 45220 |
| 513 | Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | United States | 45229 |
| 514 | Bethesda North Hospital | Cincinnati | Ohio | United States | 45242 |
| 515 | Case Western Reserve University | Cleveland | Ohio | United States | 44106 |
| 516 | Rainbow Babies and Childrens Hospital | Cleveland | Ohio | United States | 44106 |
| 517 | MetroHealth Medical Center | Cleveland | Ohio | United States | 44109 |
| 518 | Cleveland Clinic Foundation | Cleveland | Ohio | United States | 44195 |
| 519 | Ohio State University Comprehensive Cancer Center | Columbus | Ohio | United States | 43210 |
| 520 | Mount Carmel East Hospital | Columbus | Ohio | United States | 43213 |
| 521 | Riverside Methodist Hospital | Columbus | Ohio | United States | 43214 |
| 522 | Grant Medical Center | Columbus | Ohio | United States | 43215 |
| 523 | The Mark H Zangmeister Center | Columbus | Ohio | United States | 43219 |
| 524 | Mount Carmel Health Center West | Columbus | Ohio | United States | 43222 |
| 525 | Doctors Hospital | Columbus | Ohio | United States | 43228 |
| 526 | Delaware Health Center-Grady Cancer Center | Delaware | Ohio | United States | 43015 |
| 527 | Dublin Methodist Hospital | Dublin | Ohio | United States | 43016 |
| 528 | Saint Rita's Medical Center | Lima | Ohio | United States | 45801 |
| 529 | OhioHealth Mansfield Hospital | Mansfield | Ohio | United States | 44903 |
| 530 | Marietta Memorial Hospital | Marietta | Ohio | United States | 45750 |
| 531 | Licking Memorial Hospital | Newark | Ohio | United States | 43055 |
| 532 | Newark Radiation Oncology | Newark | Ohio | United States | 43055 |
| 533 | Southern Ohio Medical Center | Portsmouth | Ohio | United States | 45662 |
| 534 | ProMedica Flower Hospital | Sylvania | Ohio | United States | 43560 |
| 535 | ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital | Toledo | Ohio | United States | 43606 |
| 536 | Saint Vincent Mercy Medical Center | Toledo | Ohio | United States | 43608 |
| 537 | Mercy Health - Saint Anne Hospital | Toledo | Ohio | United States | 43623 |
| 538 | Toledo Clinic Cancer Centers-Toledo | Toledo | Ohio | United States | 43623 |
| 539 | University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | United States | 45069 |
| 540 | Saint Ann's Hospital | Westerville | Ohio | United States | 43081 |
| 541 | UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | United States | 44145 |
| 542 | Genesis Healthcare System Cancer Care Center | Zanesville | Ohio | United States | 43701 |
| 543 | Cancer Centers of Southwest Oklahoma Research | Lawton | Oklahoma | United States | 73505 |
| 544 | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | United States | 73104 |
| 545 | Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | United States | 73120 |
| 546 | Saint Charles Health System | Bend | Oregon | United States | 97701 |
| 547 | Clackamas Radiation Oncology Center | Clackamas | Oregon | United States | 97015 |
| 548 | Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | United States | 97015 |
| 549 | Bay Area Hospital | Coos Bay | Oregon | United States | 97420 |
| 550 | Providence Newberg Medical Center | Newberg | Oregon | United States | 97132 |
| 551 | Providence Portland Medical Center | Portland | Oregon | United States | 97213 |
| 552 | Providence Saint Vincent Medical Center | Portland | Oregon | United States | 97225 |
| 553 | Kaiser Permanente Northwest | Portland | Oregon | United States | 97227 |
| 554 | Legacy Emanuel Children's Hospital | Portland | Oregon | United States | 97227 |
| 555 | Oregon Health and Science University | Portland | Oregon | United States | 97239 |
| 556 | Lehigh Valley Hospital-Cedar Crest | Allentown | Pennsylvania | United States | 18103 |
| 557 | Lehigh Valley Hospital - Muhlenberg | Bethlehem | Pennsylvania | United States | 18017 |
| 558 | Christiana Care Health System-Concord Health Center | Chadds Ford | Pennsylvania | United States | 19317 |
| 559 | Geisinger Medical Center | Danville | Pennsylvania | United States | 17822 |
| 560 | Geisinger Medical Center-Cancer Center Hazleton | Hazleton | Pennsylvania | United States | 18201 |
| 561 | Geisinger Medical Oncology-Lewisburg | Lewisburg | Pennsylvania | United States | 17837 |
| 562 | Lewistown Hospital | Lewistown | Pennsylvania | United States | 17044 |
| 563 | Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | United States | 19104 |
| 564 | University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | United States | 19104 |
| 565 | Fox Chase Cancer Center | Philadelphia | Pennsylvania | United States | 19111 |
| 566 | Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | United States | 15224 |
| 567 | Geisinger Cancer Services-Pottsville | Pottsville | Pennsylvania | United States | 17901 |
| 568 | Community Medical Center | Scranton | Pennsylvania | United States | 18510 |
| 569 | Geisinger Medical Oncology-Selinsgrove | Selinsgrove | Pennsylvania | United States | 17870 |
| 570 | Reading Hospital | West Reading | Pennsylvania | United States | 19611 |
| 571 | Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre | Pennsylvania | United States | 18711 |
| 572 | Rhode Island Hospital | Providence | Rhode Island | United States | 02903 |
| 573 | Medical University of South Carolina | Charleston | South Carolina | United States | 29425 |
| 574 | Prisma Health Richland Hospital | Columbia | South Carolina | United States | 29203 |
| 575 | Gibbs Cancer Center-Gaffney | Gaffney | South Carolina | United States | 29341 |
| 576 | Saint Francis Hospital | Greenville | South Carolina | United States | 29601 |
| 577 | BI-LO Charities Children's Cancer Center | Greenville | South Carolina | United States | 29605 |
| 578 | Prisma Health Cancer Institute - Faris | Greenville | South Carolina | United States | 29605 |
| 579 | Prisma Health Greenville Memorial Hospital | Greenville | South Carolina | United States | 29605 |
| 580 | Saint Francis Cancer Center | Greenville | South Carolina | United States | 29607 |
| 581 | Prisma Health Cancer Institute - Eastside | Greenville | South Carolina | United States | 29615 |
| 582 | Prisma Health Cancer Institute - Greer | Greer | South Carolina | United States | 29650 |
| 583 | Gibbs Cancer Center-Pelham | Greer | South Carolina | United States | 29651 |
| 584 | Prisma Health Cancer Institute - Seneca | Seneca | South Carolina | United States | 29672 |
| 585 | Spartanburg Medical Center | Spartanburg | South Carolina | United States | 29303 |
| 586 | MGC Hematology Oncology-Union | Union | South Carolina | United States | 29379 |
| 587 | Sanford Cancer Center Oncology Clinic | Sioux Falls | South Dakota | United States | 57104 |
| 588 | Avera Cancer Institute | Sioux Falls | South Dakota | United States | 57105 |
| 589 | Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | United States | 57117-5134 |
| 590 | T C Thompson Children's Hospital | Chattanooga | Tennessee | United States | 37403 |
| 591 | Baptist Memorial Hospital and Cancer Center-Collierville | Collierville | Tennessee | United States | 38017 |
| 592 | East Tennessee Childrens Hospital | Knoxville | Tennessee | United States | 37916 |
| 593 | Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | United States | 38120 |
| 594 | The Children's Hospital at TriStar Centennial | Nashville | Tennessee | United States | 37203 |
| 595 | Vanderbilt University/Ingram Cancer Center | Nashville | Tennessee | United States | 37232 |
| 596 | Dell Children's Medical Center of Central Texas | Austin | Texas | United States | 78723 |
| 597 | Saint Joseph Regional Cancer Center | Bryan | Texas | United States | 77802 |
| 598 | Driscoll Children's Hospital | Corpus Christi | Texas | United States | 78411 |
| 599 | Medical City Dallas Hospital | Dallas | Texas | United States | 75230 |
| 600 | STCC at DHR Health Institute for Research and Development | Edinburg | Texas | United States | 78539 |
| 601 | El Paso Children's Hospital | El Paso | Texas | United States | 79905 |
| 602 | Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | United States | 77030 |
| 603 | M D Anderson Cancer Center | Houston | Texas | United States | 77030 |
| 604 | Covenant Children's Hospital | Lubbock | Texas | United States | 79410 |
| 605 | UMC Cancer Center / UMC Health System | Lubbock | Texas | United States | 79415 |
| 606 | Children's Hospital of San Antonio | San Antonio | Texas | United States | 78207 |
| 607 | Methodist Children's Hospital of South Texas | San Antonio | Texas | United States | 78229 |
| 608 | University of Texas Health Science Center at San Antonio | San Antonio | Texas | United States | 78229 |
| 609 | Sandra L Maxwell Cancer Center | Cedar City | Utah | United States | 84720 |
| 610 | Logan Regional Hospital | Logan | Utah | United States | 84321 |
| 611 | Intermountain Medical Center | Murray | Utah | United States | 84107 |
| 612 | McKay-Dee Hospital Center | Ogden | Utah | United States | 84403 |
| 613 | Utah Valley Regional Medical Center | Provo | Utah | United States | 84604 |
| 614 | Riverton Hospital | Riverton | Utah | United States | 84065 |
| 615 | Saint George Regional Medical Center | Saint George | Utah | United States | 84770 |
| 616 | Utah Cancer Specialists-Salt Lake City | Salt Lake City | Utah | United States | 84106 |
| 617 | Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | United States | 84112 |
| 618 | Primary Children's Hospital | Salt Lake City | Utah | United States | 84113 |
| 619 | LDS Hospital | Salt Lake City | Utah | United States | 84143 |
| 620 | University of Vermont and State Agricultural College | Burlington | Vermont | United States | 05405 |
| 621 | Norris Cotton Cancer Center-North | Saint Johnsbury | Vermont | United States | 05819 |
| 622 | Inova Fairfax Hospital | Falls Church | Virginia | United States | 22042 |
| 623 | Peninsula Cancer Institute-Gloucester | Gloucester | Virginia | United States | 23061 |
| 624 | Centra Lynchburg Hematology-Oncology Clinic Inc | Lynchburg | Virginia | United States | 24501 |
| 625 | Peninsula Cancer Institute-Newport News | Newport News | Virginia | United States | 23601 |
| 626 | Children's Hospital of The King's Daughters | Norfolk | Virginia | United States | 23507 |
| 627 | Naval Medical Center - Portsmouth | Portsmouth | Virginia | United States | 23708-2197 |
| 628 | Virginia Cancer Institute | Richmond | Virginia | United States | 23229 |
| 629 | Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | United States | 23298 |
| 630 | Peninsula Cancer Institute-Williamsburg | Williamsburg | Virginia | United States | 23185 |
| 631 | Providence Regional Cancer System-Aberdeen | Aberdeen | Washington | United States | 98520 |
| 632 | Overlake Medical Center | Bellevue | Washington | United States | 98004 |
| 633 | PeaceHealth Saint Joseph Medical Center | Bellingham | Washington | United States | 98225 |
| 634 | Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton | Washington | United States | 98310 |
| 635 | Harrison Medical Center | Bremerton | Washington | United States | 98310 |
| 636 | Highline Medical Center-Main Campus | Burien | Washington | United States | 98166 |
| 637 | Providence Regional Cancer System-Centralia | Centralia | Washington | United States | 98531 |
| 638 | Swedish Cancer Institute-Edmonds | Edmonds | Washington | United States | 98026 |
| 639 | Providence Regional Cancer Partnership | Everett | Washington | United States | 98201 |
| 640 | Swedish Cancer Institute-Issaquah | Issaquah | Washington | United States | 98029 |
| 641 | Kadlec Clinic Hematology and Oncology | Kennewick | Washington | United States | 99336 |
| 642 | Providence Regional Cancer System-Lacey | Lacey | Washington | United States | 98503 |
| 643 | PeaceHealth Saint John Medical Center | Longview | Washington | United States | 98632 |
| 644 | Valley Medical Center | Renton | Washington | United States | 98055 |
| 645 | Seattle Children's Hospital | Seattle | Washington | United States | 98105 |
| 646 | Swedish Medical Center-Ballard Campus | Seattle | Washington | United States | 98107 |
| 647 | Fred Hutchinson Cancer Research Center | Seattle | Washington | United States | 98109 |
| 648 | Swedish Medical Center-First Hill | Seattle | Washington | United States | 98122-4307 |
| 649 | University of Washington Medical Center - Montlake | Seattle | Washington | United States | 98195 |
| 650 | PeaceHealth United General Medical Center | Sedro-Woolley | Washington | United States | 98284 |
| 651 | Providence Sacred Heart Medical Center and Children's Hospital | Spokane | Washington | United States | 99204 |
| 652 | Mary Bridge Children's Hospital and Health Center | Tacoma | Washington | United States | 98405 |
| 653 | Northwest Medical Specialties PLLC | Tacoma | Washington | United States | 98405 |
| 654 | Madigan Army Medical Center | Tacoma | Washington | United States | 98431 |
| 655 | PeaceHealth Southwest Medical Center | Vancouver | Washington | United States | 98664 |
| 656 | Providence Saint Mary Regional Cancer Center | Walla Walla | Washington | United States | 99362 |
| 657 | North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | United States | 98902 |
| 658 | West Virginia University Charleston Division | Charleston | West Virginia | United States | 25304 |
| 659 | ThedaCare Regional Cancer Center | Appleton | Wisconsin | United States | 54911 |
| 660 | Ascension Saint Elizabeth Hospital | Appleton | Wisconsin | United States | 54915 |
| 661 | Duluth Clinic Ashland | Ashland | Wisconsin | United States | 54806 |
| 662 | Northwest Wisconsin Cancer Center | Ashland | Wisconsin | United States | 54806 |
| 663 | Ascension Southeast Wisconsin Hospital - Elmbrook Campus | Brookfield | Wisconsin | United States | 53045 |
| 664 | Aurora Cancer Care-Southern Lakes VLCC | Burlington | Wisconsin | United States | 53105 |
| 665 | Ascension Calumet Hospital | Chilton | Wisconsin | United States | 53014 |
| 666 | HSHS Sacred Heart Hospital | Eau Claire | Wisconsin | United States | 54701 |
| 667 | Marshfield Medical Center-EC Cancer Center | Eau Claire | Wisconsin | United States | 54701 |
| 668 | Mayo Clinic Health System-Eau Claire Clinic | Eau Claire | Wisconsin | United States | 54701 |
| 669 | Mayo Clinic Health System Eau Claire Hospital-Luther Campus | Eau Claire | Wisconsin | United States | 54703 |
| 670 | Ascension Saint Francis - Reiman Cancer Center | Franklin | Wisconsin | United States | 53132 |
| 671 | Ascension Southeast Wisconsin Hospital - Franklin | Franklin | Wisconsin | United States | 53132 |
| 672 | Aurora Health Care Germantown Health Center | Germantown | Wisconsin | United States | 53022 |
| 673 | Aurora Cancer Care-Grafton | Grafton | Wisconsin | United States | 53024 |
| 674 | Saint Vincent Hospital Cancer Center Green Bay | Green Bay | Wisconsin | United States | 54301 |
| 675 | Saint Vincent Hospital Cancer Center at Saint Mary's | Green Bay | Wisconsin | United States | 54303 |
| 676 | Aurora BayCare Medical Center | Green Bay | Wisconsin | United States | 54311 |
| 677 | Aurora Cancer Care-Kenosha South | Kenosha | Wisconsin | United States | 53142 |
| 678 | Gundersen Lutheran Medical Center | La Crosse | Wisconsin | United States | 54601 |
| 679 | Dean Hematology and Oncology Clinic | Madison | Wisconsin | United States | 53717 |
| 680 | University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | United States | 53792 |
| 681 | Aurora Bay Area Medical Group-Marinette | Marinette | Wisconsin | United States | 54143 |
| 682 | Marshfield Medical Center-Marshfield | Marshfield | Wisconsin | United States | 54449 |
| 683 | Ascension Columbia Saint Mary's Hospital Ozaukee | Mequon | Wisconsin | United States | 53097 |
| 684 | Aurora Cancer Care-Milwaukee | Milwaukee | Wisconsin | United States | 53209 |
| 685 | Ascension Southeast Wisconsin Hospital - Saint Joseph Campus | Milwaukee | Wisconsin | United States | 53210 |
| 686 | Ascension Columbia Saint Mary's Hospital - Milwaukee | Milwaukee | Wisconsin | United States | 53211 |
| 687 | Ascension Saint Francis Hospital | Milwaukee | Wisconsin | United States | 53215 |
| 688 | Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | United States | 53215 |
| 689 | Medical College of Wisconsin | Milwaukee | Wisconsin | United States | 53226 |
| 690 | Aurora Sinai Medical Center | Milwaukee | Wisconsin | United States | 53233 |
| 691 | Marshfield Clinic-Minocqua Center | Minocqua | Wisconsin | United States | 54548 |
| 692 | ProHealth D N Greenwald Center | Mukwonago | Wisconsin | United States | 53149 |
| 693 | Froedtert and MCW Moorland Reserve Health Center | New Berlin | Wisconsin | United States | 53151 |
| 694 | Cancer Center of Western Wisconsin | New Richmond | Wisconsin | United States | 54017 |
| 695 | ProHealth Oconomowoc Memorial Hospital | Oconomowoc | Wisconsin | United States | 53066 |
| 696 | Saint Vincent Hospital Cancer Center at Oconto Falls | Oconto Falls | Wisconsin | United States | 54154 |
| 697 | Ascension Mercy Hospital | Oshkosh | Wisconsin | United States | 54904 |
| 698 | Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh | Wisconsin | United States | 54904 |
| 699 | Ascension All Saints Hospital | Racine | Wisconsin | United States | 53405 |
| 700 | Aurora Cancer Care-Racine | Racine | Wisconsin | United States | 53406 |
| 701 | Ascension Saint Mary's Hospital | Rhinelander | Wisconsin | United States | 54501 |
| 702 | Marshfield Medical Center-Rice Lake | Rice Lake | Wisconsin | United States | 54868 |
| 703 | Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan | Wisconsin | United States | 53081 |
| 704 | Ascension Saint Michael's Hospital | Stevens Point | Wisconsin | United States | 54481 |
| 705 | Marshfield Medical Center-River Region at Stevens Point | Stevens Point | Wisconsin | United States | 54482 |
| 706 | Saint Vincent Hospital Cancer Center at Sturgeon Bay | Sturgeon Bay | Wisconsin | United States | 54235-1495 |
| 707 | Aurora Medical Center in Summit | Summit | Wisconsin | United States | 53066 |
| 708 | Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers | Wisconsin | United States | 54241 |
| 709 | UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | United States | 53188 |
| 710 | Ascension Medical Group Southeast Wisconsin - Mayfair Road | Wauwatosa | Wisconsin | United States | 53226 |
| 711 | Aurora Cancer Care-Milwaukee West | Wauwatosa | Wisconsin | United States | 53226 |
| 712 | Aurora West Allis Medical Center | West Allis | Wisconsin | United States | 53227 |
| 713 | Diagnostic and Treatment Center | Weston | Wisconsin | United States | 54476 |
| 714 | Marshfield Medical Center - Weston | Weston | Wisconsin | United States | 54476 |
| 715 | Marshfield Clinic - Wisconsin Rapids Center | Wisconsin Rapids | Wisconsin | United States | 54494 |
| 716 | Welch Cancer Center | Sheridan | Wyoming | United States | 82801 |
| 717 | BCCA-Vancouver Cancer Centre | Vancouver | British Columbia | Canada | V5Z 4E6 |
| 718 | BCCA-Vancouver Island Cancer Centre | Victoria | British Columbia | Canada | V8R 6V5 |
| 719 | Atlantic Health Sciences Corporation-Saint John Regional Hospital | Saint John | New Brunswick | Canada | E2L 4L2 |
| 720 | QEII Health Sciences Centre/Nova Scotia Health Authority | Halifax | Nova Scotia | Canada | B3H 2Y9 |
| 721 | Kingston Health Sciences Centre | Kingston | Ontario | Canada | K7L 2V7 |
| 722 | Ottawa Hospital and Cancer Center-General Campus | Ottawa | Ontario | Canada | K1H 8L6 |
| 723 | Hospital for Sick Children | Toronto | Ontario | Canada | M5G 1X8 |
| 724 | University Health Network-Princess Margaret Hospital | Toronto | Ontario | Canada | M5G 2M9 |
| 725 | The Montreal Children's Hospital of the MUHC | Montreal | Quebec | Canada | H3H 1P3 |
| 726 | The Research Institute of the McGill University Health Centre (MUHC) | Montreal | Quebec | Canada | H3H 2R9 |
| 727 | Centre Hospitalier Universitaire Sainte-Justine | Montreal | Quebec | Canada | H3T 1C5 |
| 728 | CHA Hopital L'Enfant-Jesus | Quebec City | Quebec | Canada | G1J 1Z4 |
| 729 | Allan Blair Cancer Centre | Regina | Saskatchewan | Canada | S4T 7T1 |
| 730 | Centre Hospitalier Universitaire de Quebec | Quebec | Canada | G1V 4G2 | |
| 731 | HIMA San Pablo Oncologic Hospital | Caguas | Puerto Rico | 00726 | |
| 732 | University Pediatric Hospital | San Juan | Puerto Rico | 00926 |
Sponsors and Collaborators
- National Cancer Institute (NCI)
Investigators
- Principal Investigator: Alex F Herrera, Southwest Oncology Group
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.Responsible Party:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT03907488
Other Study ID Numbers:
- NCI-2019-01960
- NCI-2019-01960
- S1826
- S1826
- U10CA180888
First Posted:
Apr 9, 2019
Last Update Posted:
Aug 25, 2022
Last Verified:
Apr 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Yes
Plan to Share IPD:
Yes
Studies a U.S. FDA-regulated Drug Product:
Yes
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms: