STRING: Prevalence of Major Depression Among Immigrants in Santiago, Chile

Sponsor

Pontificia Universidad Catolica de Chile (Other)

Overall Status

Completed

CT.gov ID

NCT04114565

Collaborator

Fondo Nacional de Desarrollo Científico y Tecnológico, Chile (Other)

1,092

Enrollment

Location

11.1

Actual Duration (Months)

98.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The general aim of this study is to explore the prevalence of major depressive disorder and the use of mental health services in the immigrant populations in the Metropolitan Region of Santiago, Chile.

The hypotheses are:

A healthy immigrant effect will be observed in the studied population by which their prevalence of major depressive disorder will be lower than the prevalence in the general Chilean population.
A significant association will be observed between the loss of socio-economic position after migration and a greater probability of major depressive disorder.
A significant association will be observed between the report of victimization experience(s) in the previous year and a greater probability of major depressive disorder.
A significant association will be observed between financial difficulties and a greater probability of major depressive disorder.

The sampling framework of the Chilean National Institute of Statistics (INE) from the 2016

Census will be used for the purpose of this research. The sampling units are as follows:

Primary sampling units (PSUs): conglomerates or groups of adjoining houses, organized in spatial blocks (200 households on average)
Secondary sampling units (SSUs): individual households within each of the conglomerates selected in the first stage
Final sampling units: persons meeting the study's inclusion criteria Multi-stage random probability sampling involving a 3-stage sampling design will be used - first, the sampling of the primary sampling units (PSUs); second, the sampling of households within the selected PSUs and finally, the random sampling of a household member.

Participants (n=1,100) will then take part in a 45-minute interview. This interview will be a household survey using the modular version of the Composite International Diagnostic Interview (WHO-CIDI) looking at exploring a broad spectrum of factors traditionally associated with increased risk of affective disorders:

Sociodemographics
Finance
Variation in socioeconomic position
Experience of victimization
Discrimination
Experience of childhood adversity

Condition or Disease	Intervention/Treatment	Phase
Major Depressive Disorder

Study Design

Study Type:

Observational

Actual Enrollment :

1092 participants

Observational Model:

Ecologic or Community

Time Perspective:

Cross-Sectional

Official Title:

The Santiago Immigrant Wellbeing Study (STRING): Prevalence of Mood Disorders Among Immigrants in Santiago, Chile

Actual Study Start Date :

Jul 29, 2019

Actual Primary Completion Date :

Nov 30, 2019

Actual Study Completion Date :

Jun 30, 2020

Outcome Measures

Primary Outcome Measures

Major Depressive Disorder [baseline]
Assessed using the World Health Organisation Composite International Diagnostic Interview (WHO-CIDI)
Any affective/mood disorder [baseline]
Assessed using the WHO-CIDI
Suicidal ideation, plans and attempts [baseline]
Assessed using the WHO-CIDI
Depressive symptoms [baseline]
Assessed using the nine-item Patient Health Questionnaire (PHQ-9). The PHQ-9 score can range from 0 to 27, with the following severity scores: 0-4 None; 5-9 Mild; 10-14 Moderate; 15-19 Moderate to Severe; 20-27 Severe.
Anxiety symptoms [baseline]
Assessed using the Generalized Anxiety Disorder 7-item scale (GAD-7). The GAD-7 score can range from 0 to 21, with the following severity scores: 0-4 None; 5-9 Mild; 10-14 Moderate; 15-21 Severe.

Secondary Outcome Measures

Mental wellbeing [baseline]
Assessed using the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS). The 14 Items are scored on a range from 1 to 5, providing a total score between 14 and 70 with higher values indicating higher mental well-being.
Mental health service use [baseline]
Assessed using items of the Services Module of the WHO-CIDI
Hazardous/harmful drinking [baseline]
Assessed using the Alcohol Use Disorders Identification Test (AUDIT)